Results 61 to 70 of about 12,864,962 (300)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Impact of tilt angle, dust deposition, and humidity on potential induced degradation and electrical performance of crystalline silicon photovoltaic modules: an experimental study

Electrical engineering & Electromechanics
Introduction. Photovoltaic (PV) modules constitute the backbone of renewable energy systems, yet their performance is compromised by degradation mechanisms, particularly potential induced degradation (PID), which causes rapid power losses through ionic ...
Z. Khammassi, A. Jeridi, H. Khaterchi, A. Zaafouri   +3 more
doaj   +1 more source

Macrophages induce gingival destruction via Piezo1-mediated MMPs-degrading collagens in periodontitis

Frontiers in Immunology, 2023
Macrophages are an integral part of the innate immune response in periodontal tissue and play a crucial role in the progression of periodontitis. Here we reported that macrophages also provoke periodontitis-induced gingival destruction through Piezol ...
Tong Zhao, Tong Zhao, Zhuangzhuang Chu, Zhuangzhuang Chu, Catherine Huihan Chu, Catherine Huihan Chu, Shuo Dong, Shuo Dong, Guoqing Li, Guoqing Li, Jin Wu, Jin Wu, Chunbo Tang, Chunbo Tang   +13 more
doaj   +1 more source

Diagnostics of potential induced degradation in photovoltaics

Journal of International Scientific Publications: Materials, Methods and Technologies, 2014
The aim of this paper is the investigation of electrical and mechanical properties of solar cells assembled into modules, before and after accelerated ageing. It was shown that impedance spectroscopy measurement and characterization is an important tool to reveal the degradation due to high voltage stress and increased temperature stress.
Saly, Vladimir, Vary, Michal, Schlosser, Viktor, Packa, Juraj, Perný, Milan, Firický, Eduard, Kulich, Ondrej, Ďurman, Vladimír   +7 more
openaire   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Material Collected From the Induced Seismicity State Task Force Meeting, Wednesday, April 16, 2014, Newman University, Wichita, Kansas

, 2014
Announcement -- Agenda -- Breakout Sessions: Questions and Responses -- An Ounce of Understanding is Worth a Pound of Cure / by Kyle E. Murray -- Induced Seismicity and the Oil and Gas Industry -- Overview of Kansas Earthquakes / Rick Miller, Shelby ...
Induced Seismicity State Task Force Meeting (2014 : Wichita, Kan.)
core   +1 more source

Identification of radiation induced dark current sources in pinned photodiode CMOS image sensors [PDF]

, 2011
This paper presents an investigation of Total Ionizing Dose induced dark current sources in Pinned PhotoDiodes (PPD) CMOS Image Sensors based on pixel design variations. The influence of several layout parameters is studied. Only one parameter is changed
V. Goiffon, Goiffon, Vincent, C. Virmontois, M. Gaillardin, Gaillardin, Marc, P. Magnan, P. Martin-Gonthier, Virmontois, Cédric, Girard, Sylvain, P. Paillet, Paillet, Philippe, S. Girard, Cervantes, Paola, P. Cervantes, Magnan, Pierre, Martin-Gonthier, Philippe   +15 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Identification of radiation induced dark current sources in pinned photodiode CMOS image sensors [PDF]

, 2012
This paper presents an investigation of Total Ionizing Dose induced dark current sources in Pinned PhotoDiodes (PPD) CMOS Image Sensors based on pixel design variations. The influence of several layout parameters is studied. Only one parameter is changed
Goiffon, Vincent, Place, Sébastien, Gaillardin, Marc, Estribeau, Magali, Virmontois, Cédric, Girard, Sylvain, Magnan, P., Gaillardin, M., Martin-Gonthier, P., Cervantes, P., Paillet, Philippe, Cervantes, Paola, Magnan, Pierre, Martin-Gonthier, Philippe   +13 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source