Results 271 to 280 of about 5,371,394 (318)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A Sensitivity Analysis Framework Using the Proxy Pattern-Mixture Model for Generalization of Experimental Results. [PDF]

Stat Med
Andridge RR, Song R, West BT.
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Causal machine learning methods for understanding land use and land cover change. [PDF]

Landsc Ecol
Eigenbrod F, Alexander P, Apfel N, Athanasiadis IN, Berger T, Bullock JM, Duveiller G, Equihua J, Menezes I, Moreira R, Paudel D, Sitokonstantinou V, Reichstein M, Willcock S, Woodman T.   +14 more
europepmc   +1 more source

Pregnancy identification method as a source of bias in studies of prenatal exposures using real-world data. [PDF]

Am J Epidemiol
Latour CD, Edwards JK, Funk MJ, Suarez EA, Boggess K, Wood ME.   +5 more
europepmc   +1 more source

Early peripheral blood gene expression predicts 90-day outcomes following subarachnoid hemorrhage. [PDF]

J Neuroinflammation
Knepp B, Lenz GH, Sharp FR, Rodriguez F, Choi HA, Gusdon AM, Jickling G, Zimmermann LL, Martin R, Vitt J, Waldau B, Cord BJ, Yee A, Ng K, Ko NU, Hull H, Ander BP, Stamova B.   +17 more
europepmc   +1 more source

The threat of serious outcome reporting bias in randomized controlled trials on acute ischemic stroke to evidence synthesis: a meta-epidemiological study. [PDF]

Cardiovasc Diagn Ther
Zhang N, Long Y, Wang X, Wang X, Guo Q, Li Z, Du L.   +6 more
europepmc   +1 more source

Conceptualizing Experimental Controls Using the Potential Outcomes Framework. [PDF]

Am Stat
Hunter KB, Koenig K, Bind MA.
europepmc   +1 more source