Results 71 to 80 of about 842,331 (261)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Predicting potentially suitable Bletilla striata habitats in China under future climate change scenarios using the optimized MaxEnt model

Scientific Reports
Bletilla striata, an important traditional Chinese medicine resource, holds high medicinal and ornamental value. However, unscientific habitat selection for its cultivation has led to low yields and poor quality as medicinal materials in China.
Ming Luo, Pingfei Yang, Lili Yang, Zhihong Zheng, Yaya Chen, Huan Li, Mingkai Wu   +6 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Prediction and Driving Study of Prunus armeniaca L. Habitat in the Yili River Valley under the Background of Climate Change [PDF]

BIO Web of Conferences
Prunus armeniaca L. is the native species of cultivated apricot, which is important information for studying the origin, succession pattern, pest control, sustainable development of biodiversity of economic tree species of the genus Apricot, etc. However,
Ning Ang, Chen Wanji, Zhao Yang, Cui Wenbing, Saydahmat Muyassar, Akberjan Erfan   +5 more
doaj   +1 more source

Effects of water level fluctuation on the potential habitat area of Vallisneria natans in Poyang Lake

Shui kexue jinzhan, 2020
As the dominant submerged macrophytes in Poyang Lake, the winter buds of Vallisneria natans provide food for wintering waterbirds. In order to quantify the effects of water level fluctuation on the habitat area of Vallisneria natans in Poyang Lake, a ...
Liangang CHEN, Liming CHEN, Yifang XU, Zhenyu LUAN, Qiu JIN, Yong SHI, Tengfei HU   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Predicting Climate Change-Induced Habitat Contraction of Disanthus cercidifolius subsp. longipes: A Warning Signal for Endemic Species Conservation

Biology
Global climate change is reshaping the distribution of suitable habitats for plant survival, with particularly severe implications for endangered plant species.
Qitao Su, Yulu Li, Haiyan Xiao, Yuxin Huo, Muhammad Umair Hassan, Xiaohong Yan, Zhixuan Du, Bing Zhou   +7 more
doaj   +1 more source

Predicting Potential Suitable Areas of Dendrocalamus brandisii under Global Climate Change

Forests
Climate change restricts and alters the distribution range of plant species. Predicting potential distribution and population dynamics is crucial to understanding species’ geographical distribution characteristics to harness their economic and ecological benefits.
Hang Tao, Kate Kingston, Zhihong Xu, Shahla Hosseini Bai, Lei Guo, Guanglu Liu, Chaomao Hui, Weiyi Liu   +7 more
openaire   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Potential Geographic Distribution and Suitable Area of Three Species of Diabrotica (Coleoptera: Chrysomelidae) Beetles in Corn-Planting Regions of China

Insects
Corn rootworms of Diabrotica virgifera virgifera Le Conte, 1868; Diabrotica undecimpunctata howardi Barber, 1947, and Diabrotica barberi R.F. Smith & Lawrence, 1967 are important pests of corn crops that natively occur in America and have a potential ...
Yening Jin, Fan Shao, Sizhu Zheng, Yumeng Wang, Gao Hu, Fajun Chen   +5 more
doaj   +1 more source