Results 91 to 100 of about 14,945,351 (305)

The potential of high resolution palaeoclimate reconstruction from Arctica islandica [PDF]

open access: yes, 2008
The potential of Arctica islandica, a long lived marine bivalve with a lifespan of over 300 years, to reconstruct a high resolution (sub-annual) climate record is explored in this thesis.
Foster, Laura
core   +2 more sources

Nitrogen-doped carbon nanoparticles for potential temperature sensing applications

open access: yesSensing and Bio-Sensing Research, 2019
In this study, fluorescent nitrogen-doped carbon nanoparticles (N-CNPs) were prepared using a facile and green hydrothermal method. A number of characterization techniques were employed to analyze the physicochemical properties of prepared N-CNPs ...
Timur Sh. Atabaev   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Thermal Properties of Two Materials Commonly Usedin Low Temperature Laboratories [PDF]

open access: yes, 2013
We carried out measurements of thermal conductance and thermal contact resistance of two materials commonly used in low temperature laboratories such as an Electro-Magnetic Interference (EMI) Filter and Stycast 2850 FT epoxy.
ANGEL ENRIQUE SANCHEZ COLIN
core  

Impacts of climatic condition and its change on the temperature suitability and potential productivity of rice in the Yangtze River delta of China

open access: yes浙江大学学报. 农业与生命科学版, 2000
This paper presents the temperature suitability assessment function and the calculation models of potential productivity for crops, and determined the relevant parameters for rice according to field tests and statistic analysis, and analyzed the impacts ...
LI Quan-sheng, YE Xu-jun, YANG Zhong-en
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

TPTNet: A Data‐Driven Temperature Prediction Model Based on Turbulent Potential Temperature

open access: yesEarth and Space Science
A data‐driven model for predicting the surface temperature using neural networks was proposed to alleviate the computational burden of numerical weather prediction (NWP).
Jun Park, Changhoon Lee
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Abschirmung schwerer Quarks und Hadronen bei endlicher Temperatur und Dichte [PDF]

open access: yes, 2006
Döring M. Screening of heavy quarks and hadrons at finite temperature and density. Bielefeld (Germany): Bielefeld University; 2006.Schwere Quarks und Hadronen werden in einem thermischen und baryon-chemischen Medium abgeschirmt.
Döring, Matthias
core  

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