Results 81 to 90 of about 14,945,351 (305)

Trends in surface equivalent potential temperature: A more comprehensive metric for global warming and weather extremes. [PDF]

Proc Natl Acad Sci U S A, 2022
Song F, Zhang GJ, Ramanathan V, Leung LR.   +3 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Geophysical Methods for Monitoring Temperature Changes in Shallow Low Enthalpy Geothermal Systems

Energies, 2014
Low enthalpy geothermal systems exploited with ground source heat pumps or groundwater heat pumps present many advantages within the context of sustainable energy use.
Thomas Hermans, Frédéric Nguyen, Tanguy Robert, Andre Revil   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Influence of temperature on the larval development of the edible crab Cancer pagurus [PDF]

, 2009
The influence of temperature on larval survival and development was studied in the edible crab, Cancer pagurus, from a population off the Island of Helgoland, North Sea.
Keller, Martina, Thatje, S., Heilmayer, O., Anger, Klaus, Weiss, Monika, Heilmayer, Olaf, Anger, K., Brey, T., Brey, Thomas, Weiss, M.   +9 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Glueball mass estimate from finite temperature SU(2) lattice studies [PDF]

, 1981
Engels J, Karsch F, Satz H, Montvay I. Glueball mass estimate from finite temperature SU(2) lattice studies. Physics Letters, B.
Karsch, Frithjof, Engels, Jürgen, Satz, Helmut, Montvay, I.   +3 more
core   +1 more source

Quark potentials at finite temperatures

Zeitschrift für Physik C Particles and Fields, 1985
We scan the quark-antiquark potential and the meson-meson potential for static quarks in aSU3 gluon field from strong coupling to weak coupling. The breakdown of the confinement between quark and antiquark at the phase transition is observed. There is no interaction between pointlike mesons in the whole coupling regime.
C. Dorninger, H. Leeb, H. Markum, M. Meinhart   +3 more
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Temperature sensitivity of the pyloric neuromuscular system and its modulation by dopamine [PDF]

, 2013
We report here the effects of temperature on the p1 neuromuscular system of the stomatogastric system of the lobster (Panulirus interruptus). Muscle force generation, in response to both the spontaneously rhythmic in vitro pyloric network neural activity
Kevin H. Hobbs, Burstein, Helaine J., Hooper, Scott L., Jeffrey B Thuma, Kevin H Hobbs, Seiter, Natasha S., Scott L. Hooper, Hobbs, Kevin H., Natasha S. Seiter, Scott L Hooper, Natasha S Seiter, Jeffrey B. Thuma, Helaine J. Burstein, Thuma, Jeffrey B., Helaine J Burstein, Thuma Jeffrey B., Burstein Helaine J., Seiter Natasha S., Hobbs Kevin H., Hooper Scott L.   +19 more
core   +2 more sources