Results 81 to 90 of about 2,802,423 (315)
Geophysical Methods for Monitoring Temperature Changes in Shallow Low Enthalpy Geothermal Systems
Energies, 2014 Low enthalpy geothermal systems exploited with ground source heat pumps or groundwater heat pumps present many advantages within the context of sustainable energy use.
Thomas Hermans +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2015 Funding for this research came from The Buckland Foundation, The Scottish Fisheries Museum Trust Ltd. Additional costs and supplies were provided by the School of Biology of The University of St Andrews.Guppies have successfully established populations ...
Kent, Maud +3 more
core +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Temperature effect on space charge dynamics in XLPE insulation
, 2007 This paper reports on space charge evolution in crosslinked polyethylene (XLPE) planar samples approximately 1.20 mm thick subjected to electric stress level of 30 kVdc/mm under four temperature 25 oC, 50 oC, 70 oC and 90 oC for 24 hours.
Y.l. Chong +7 more
core +1 more source
Temperature-dependent for Zika and dengue.
, 2023 For vector-borne diseases the basic reproduction number , a measure of a disease’s epidemic potential, is highly temperature-dependent. Recent work characterizing these temperature dependencies has highlighted how climate change may impact geographic ...
Joseph N. S. Eisenberg (9356559) +2 more
core +1 more source
Nitrogen-doped carbon nanoparticles for potential temperature sensing applications
Sensing and Bio-Sensing Research, 2019 In this study, fluorescent nitrogen-doped carbon nanoparticles (N-CNPs) were prepared using a facile and green hydrothermal method. A number of characterization techniques were employed to analyze the physicochemical properties of prepared N-CNPs ...
Timur Sh. Atabaev +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source