Results 91 to 100 of about 6,014,967 (278)
Diffuse sound field synthesis: Ideal source layers
Acta AcusticaCan uncorrelated surrounding sound sources be used to generate extended diffuse sound fields? By definition, targets are a constant sound pressure level, a vanishing active sound intensity, and uncorrelated sound waves arriving isotropically from all ...
Zotter Franz +3 more
doaj +1 more source
Some remarks on the Dirichlet problem on infinite trees
Concrete Operators, 2019 We consider the Dirichlet problem on in_nite and locally _nite rooted trees, andwe prove that the set of irregular points for continuous data has zero capacity. We also give some uniqueness results for solutions in Sobolev W1,p of the tree.
Chalmoukis Nikolaos, Levi Matteo
doaj +1 more source
Ring-Polymer Instanton Tunneling Splittings of Tropolone and Isotopomers using a Δ-Machine Learned CCSD(T) Potential: Theory and Experiment Shake Hands. [PDF]
J Am Chem Soc, 2023 Nandi A +12 more
europepmc +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Positive solutions for systems of competitive fractional differential equations
Electronic Journal of Differential Equations, 2016 Using potential theory arguments, we study the existence and boundary behavior of positive solutions in the space of weighted continuous functions, for the fractional differential system $$\displaylines{ D^{\alpha }u(x)+p(x)u^{a_1}(x)v^{b_1}(x) =0 ...
Majda Chaieb +2 more
doaj
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Review of progress and prospect of modern constitutive theories for soils
Yantu gongcheng xuebao, 2018 The constitutive model for soils is the core and key of modern soil mechanics. Since the creation of Cambridge elasto-plastic model, the constitutive model for soils has been studied for more than 50 years, and hundreds of models have been established ...
YANG Guang-hua
doaj +1 more source