Results 101 to 110 of about 50,482 (310)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
For Aïsha: On Identity as Potentiality [PDF]
, 2012 The focal point of this article is identity as potentiality: how a narrated form of self-understanding can be mobilized, enacted and shared with others within unequal distributed multifaceted conditions of existence, with other outcomes than surrender to
Trondman, Mats, +2 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Potentiality or potency. Introduction to the problems [PDF]
, 2013 The aim of the article is to show how the Aristotelian contents “potentiality” and “potency” have been mixed up in the Arabic legacy, especially in Avicennian philosophy.
Prokop, Marek P.
core
Potentiality in the Psychological Analysis of Development [PDF]
, 2020 In the paper the author presents the classic conception of the zone of proximal development (ZPD) and the directions of its development and redefinition. In the analyses of ZPD we find a variety of aspects. They make the point of departure for the search
Rzechowska, Ewa
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The Anthropology of Potentiality in Biomedicine:An Introduction to Supplement 7 [PDF]
, 2013 At the beginning of the twenty-first century, potentiality serves as a central concept in the life sciences and in medical practices. This special issue of Current Anthropology explores how genes, cells, bodies, and populations as well as technologies ...
Helmreich, Stefan +2 more
core +1 more source