Results 121 to 130 of about 50,482 (310)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Avoiding Façons de Parler: Potentiality and Possibility in Aristotle’s Philosophy [PDF]
The distinction between potentiality and possibility in Aristotle’s modal teleology is sometimes conflated by the implicative conjunction that potentiality implies possibility and possibility implies potentiality. In his unpublished doctoral dissertation
Fernández, José Luis
core
Life’s potentiality as multispecies gift [PDF]
Contemporary political ecological problems reduce possibilities for future human and non-human life. These problems are the result of modern capitalist humans’ attempt to break away from multispecies bonds and turn non-humans into resources to be ...
Aldeia, João
core +1 more source
Open PhilosophyWhile sharing some features in common with presentist accounts of time, Hegel’s theory of time fundamentally offers an alternative to standard A-Theories, B-Theories, and C-Theories of time.
Gentry Gerad
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
QCD potential as a “Coulomb-plus-linear” potential
Physics Letters B, 2003 Version to appear in Phys.Lett.B; Explanations on derivation added; Leading ultrasoft logs included in the analysis (Sec.5);12 pages,4 ...
openaire +3 more sources
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Pure Temporal Potentiality: An Ontological Window [PDF]
This paper presents Pure Temporal Potentiality (PTP) — the fundamental ontological insight that reality is pure temporality as potentiality: ontorealis.
Harder, Stig
core +3 more sources