Results 91 to 100 of about 372,494 (306)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Atmospheric Research and Monitoring Study of Hazardous Substances [PDF]
, 1985 Hazardous Waste Research and Information Center Illinois Department of Energy and Natural ...
Gatz, Donald F., Sweet, Clyde W.
core
Potentially Toxic Elements Contamination in Urban Soils
Journal of Environmental Quality, 2007 ABSTRACTStudies on several cities around the world confirm that urban soils are subject to heavy anthropogenic disturbance. However, these surveys are difficult to compare due to a lack of common sampling and analytical protocols. In this study the soils of Ljubljana (Slovenia), Sevilla (Spain), and Torino (Italy) were extensively sampled and analyzed ...
BIASIOLI, Mattia +5 more
openaire +4 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Determination of Silver Binding to Natural Organic Matter Using Ion Selective Electrode [PDF]
, 2017 Natural organic matter (NOM) is considered an important factor in the protection of the aquatic environments; organic ligands can complex with metals, to decrease their toxicity and bioavailability. NOM is measured as dissolved organic carbon (DOC) in mg
Alshammari, Mona Muhawwis
core +1 more source
Accumulation of Potentially Toxic Elements in Agricultural Soils
, 2021 Soil health is threatened by many processes associated with intensive agriculture. This study highlights the inadequacies of the current direct and indirect legal instruments to protect soils from one of these threats: the accumulation of potentially toxic elements (PTES).
Green, Iain D. +3 more
openaire
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
ToxicsThe study aimed to determine the content of 17 elements (Al, As, Ba, Cd, Co, Cr, Cu, Fe, Li, Mn, Mo, Ni, Pb, Sb, Se, Sr, and Zn) in samples of sheep milk, cheese, and whey (36 samples in total) collected from a farm in an environmentally burdened area ...
Simona Almášiová +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Dried blood spots in toxicology : from the cradle to the grave? [PDF]
, 2012 About a century after its first described application by Ivar Bang, the potential of sampling via dried blood spots (DBS) as an alternative for classical venous blood sampling is increasingly recognized.
De Kesel, Pieter +3 more
core +1 more source