Results 91 to 100 of about 100,354 (256)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Assessment of the concentration and health risk of potentially toxic elements in agricultural soils of the Bastam Plain (Semnan Province) [PDF]

علوم زمین خوارزمی
In order to investigate the concentration and the health risk of potentially toxic elements in the agricultural soils of the Bastam Plain, 14 surface soil samples (0-20 cm) were collected. Physico-chemical characteristics and total concentration of major
Javid Khaghani, Giti Forghani
doaj  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Improving the growth of pea plant by biochar–polyacrylamide association to cope with heavy metal stress under sewage water application in a greenhouse

Frontiers in Environmental Science
Sewage water is extensively used for irrigation, serving as a valuable resource for plant growth to enhance agricultural productivity. However, this practice also results in a significant accumulation of heavy metals in the soil, posing potential ...
Muhammad Naveed, Maryum Fatima, Zainab Naseem, Zulfiqar Ahmad, Abdel-Rhman Z Gaafar, Mubashra Shabbir, Qurrat ul Ain Farooq, Qurrat ul Ain Farooq, Mohamed S. Hodhod, Muhammad Imran Khan, Dua Shahid, Adnan Mustafa   +11 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Sustainable groundwater management through water quality index and geochemical insights in Valsad India

Scientific Reports
Groundwater quality assessment is crucial for sustainable water resource management and public health protection. This study evaluated the Water Quality Index (WQI) of groundwater in the southern part of Gujarat focusing on the Valsad District ...
Keval H Jodhani, Nitesh Gupta, Sanidhya Dadia , Harsh Patel, Dhruvesh Patel, Punyawi Jamjareegulgarn , Sudhir Kumar Singh, Upaka Rathnayake   +7 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Potentially Toxic Elements in Local Cigarettes and Marijuana Leaves of Bauchi State, Nigeria: Public Health and Environmental Implications

Pollutants
Exposure to potentially toxic elements (PTEs) in commonly used substances remains a serious public health concern, especially in low-regulation environments. This study assessed and compared the concentrations of five PTEs, cadmium (Cd), lead (Pb), zinc (
Tasha Siame, Yisa Adeniyi Abolade, Famodu Omotayo, Albert Junior Nyarko, Mu’awiya Baba Aminu, Uchechukwu Anthony Ogwurumba, Bertha Onyenachi Akagbue, Fatima Abdulmalik, Hareyani Zabidi   +8 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Determination of source and assessment of contamination of potentially toxic elements mineral dusts of the Chadormalu Iron Mine, Bafq, Northeast of Yazd

Journal of Economic Geology
This study evaluates the concentration and source of potentially toxic elements in thirteen samples of in-situ dust collected from the Chadormalu iron mine, located 180 km northeast of Yazd city.
Shiva Mehrabani, Mohammad Maanijou , Afshin Qishlaqi, Yoriko Yokoo   +3 more
doaj   +1 more source