Results 51 to 60 of about 752,443 (346)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

High Fructose Corn Syrup Accelerates Kidney Disease and Mortality in Obese Mice with Metabolic Syndrome

open access: yesBiomolecules, 2023
The presence of obesity and metabolic syndrome is strongly linked with chronic kidney disease (CKD), but the mechanisms responsible for the association are poorly understood.
Ana Andres-Hernando   +8 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

AN ECONOMIC EVALUATION OF THE EFFICIENCY OF OPERATING AGRICULTURAL MACHINES IN PRODUCTION OF WHEAT [PDF]

open access: yesArab Universities Journal of Agricultural Sciences, 2018
Agricultural sector is considered to be one of the most important sectors in the Egyptian economy that contributes greatly in the national income. Therefore, the state pays great intention to the agricultural sector concerning all developmental aspects ...
Aziza Hussein   +3 more
doaj   +1 more source

Micro-pound extended range thrust stand Patent [PDF]

open access: yes, 1971
Micro-pound extended range thrust stand for small rocket ...
Stark, K. W.
core   +1 more source

Development of the health and economic consequences of smoking interactive model [PDF]

open access: yes, 2001
Objective-To describe the health and economic consequences of smoking model, a user friendly, web based tool, designed to estimate the health and economic outcomes associated with smoking and the benefits of smoking cessation.
Godfrey, C   +4 more
core   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

"So many people going the other way" : an examination of the moral strategy of language usage in five novels by Janet Frame : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in English at Massey University [PDF]

open access: yes, 1991
The title quotation is from Janet Frame's novel, Living in the Maniototo (72). Abbreviations and editions of the five primary sources referred to in the text are as follows: EA The Edge of the Alphabets London: W.H. Allen & Co., 1962.
Pound, Lynette Ruth
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

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