Results 181 to 190 of about 1,878,962 (383)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Relevant Alternatives in Resolving the Rural Poverty Problem [PDF]

, 1964
Lee Roy Martin
openalex   +1 more source

2007 Report on Illinois Poverty [PDF]

, 2007
This seventh annual Report on Illinois Poverty illustrates that there are many indications Illinois families are experiencing significant hardship. Over one third of Illinoisans in poverty are children, disparities in income and wealth are widening ...

core  

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Poverty: A State of Extremes [PDF]

, 2006
New York was the only state where both poverty and income exceeded national levels in 2005, with 13.8% of residents living in poverty and a median household income of $49,480.

core   +1 more source

Poverty without Poverty Line

SSRN Electronic Journal
I propose a new cardinal measure of poverty, which builds on the intuitive notion that a person with half the income of another is twice as poor. Mathematically, this implies that poverty is the reciprocal of income. The resulting aggregate measure has a simple interpretation: it is the average number of days needed to get a reference level of income ...
openaire   +2 more sources

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

The impact of home-installed growth charts and small-quantity lipid-based nutrient supplements (SQ-LNS) on child growth in Zambia: a four-arm parallel open-label cluster randomised controlled trial

BMJ Global Health
Background Childhood stunting remains common in many low-income settings and is associated with increased morbidity and mortality, as well as impaired child development.Methods The main objective of the study was to assess whether home-installed growth ...
Günther Fink, Peter C Rockers, Lindsey M Locks, Jacqueline M. Lauer, Mpela Chembe, Savanna Henderson, Dorothy Sikazwe, Tamara Billima-Mulenga, Doug Parkerson   +8 more
doaj   +1 more source

Half in Ten: Why Taking Disability into Account is Essential to Reducing Income Poverty and Expanding Economic Inclusion [PDF]

, 2009
Disability is both a fundamental cause and consequence of income poverty. The income-poverty rate for persons with disabilities is between two to three times the rate for persons without disabilities.
Shawn Fremstad
core  

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source