Results 71 to 80 of about 816,124 (307)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Working for a poverty-free Ireland: Combat Poverty Agency Strategic Plan 2005 - 2007
, 2013 Combat Poverty is a statutory agency established under the Combat Poverty Agency Act 1986. This Act sets out Combat Poverty’s functions as: policy advice; research; project support, innovation and evaluation; and public education. Under the Act we
Combat Poverty Agency (CPA)
core
Working to Reduce Poverty: A National Subsidized Employment Proposal
RSF: The Russell Sage Foundation Journal of the Social Sciences, 2018 Subsidized employment programs that increase labor supply and demand are a proven, underutilized strategy for reducing poverty in the short and long term.
Indivar Dutta-Gupta +4 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
SSRN Electronic JournalI propose a new cardinal measure of poverty, which builds on the intuitive notion that a person with half the income of another is twice as poor. Mathematically, this implies that poverty is the reciprocal of income. The resulting aggregate measure has a simple interpretation: it is the average number of days needed to get a reference level of income ...
openaire +2 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
People, poverty & participation
, 2009 The policy discussion paper is structured in four chapters: • Chapter 2 briefly discusses the relationship between participative and representative democracy. It also describes a number of participation models.
Combat Poverty Agency (CPA)
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Developing a Local anti-poverty and social inclusion strategy: A guide [PDF]
, 2007 The EU member states, including Ireland, recognise that poverty and social exclusion are critical issues they must tackle. In 1997 the Irish Government, in consultation with the social partners, community and voluntary sector and other stakeholders ...
Combat Poverty Agency (CPA)
core
The Poverty of the Ethnography of Poverty
Journal of Social Intervention: Theory and PracticeAbstract Recapitulating the three ages of “urban ethnography” born in Chicago a century ago, this book puts into historical and analytical perspective a controversy over the ethnography of nexus of race, class and morality in and around the Black American ghetto in the age of triumphant neoliberalism, in order to draw from it positive ...
openaire +2 more sources
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source