Results 121 to 130 of about 418,010 (307)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Getting to Zero HIV Cases San Francisco: Reconceptualizing Housing as HIV Prevention and HIV Treatment [PDF]

, 2019
The City and County of San Francisco, originallyground zero for the HIV epidemic in the United States, is redefining public health HIV interventions, potentially positioning San Francisco as one of the first major metropolitan cities in the world to ...
Zaragoza, Gaspar
core  

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Kesejahteraan Komunitas di Desa Adaut, Kecamatan Selaru, Provinsi Maluku [PDF]

, 2014
Adaut village inWest Southeast Maluku district as a location for research is one of the underdeveloped areas. The purpose of this study is to identify and map out the problems, the needs of the Community and the resources and potential of the research ...
Pudjianto, B. (Bambang), Suyanto, S. (Suyanto)   +1 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Geographic Decomposition of Inequality in Health and Wealth : Evidence from Cambodia [PDF]

The small-area estimation developed by Elbers, Lanjouw and Lanjouw (2002, 2003), in which a census and a survey are combined to produce the estimates of welfare measures for small geographic areas, has become a standard tool for poverty analysis in ...
Tomoki Fujii
core   +1 more source

Mapping a Healthier Future: How Spatial Analysis Can Guide Pro-Poor Water and Sanitation Planning in Uganda [PDF]

, 2009
This report is intended for technical and high-level officers working both on poverty issues and in health and water departments at national and local levels.

core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Assessment of Energy Efficiency and Energy Poverty of the Residential Building Stock of the City of Seville Using GIS

Applied Sciences
In the European Union, 75% of the residential building stock is estimated to have energy inefficiencies, which increases the probability of falling into energy poverty. Poor thermal conditions reduce the quality of life of dwelling occupants.
Antonio J. Aguilar, María L. de la Hoz-Torres, Joaquín Aguilar-Camacho, María Fernanda Guerrero-Rivera   +3 more
doaj   +1 more source

Pakistan Poverty Map 2019–2020

This paper summarizes the approach used to estimate monetary poverty for Pakistan in 2019–20 at the district level. The small area estimation method is used to impute welfare from the Household Income and Expenditure Survey 2018–19 into the Pakistan Social and Living Standard Measurement ...
Malaga Ortega, Ramiro, Meyer, Moritz, Corral Rodas, Paul   +2 more
openaire   +2 more sources