Results 121 to 130 of about 2,599,250 (332)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Asset versus consumption poverty and poverty dynamics in the presence of multiple equilibria in rural Ethiopia [PDF]
Effective poverty reduction programs require careful measurement of poverty status. Several studies have shown conceptually that assets reflecting productive capacity form a more robust basis for identifying the poor than do flow variables such as ...
Winter-Nelson, Alex +1 more
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Measuring Poverty in Nigeria [PDF]
, 2003 There is no shortage of written materials about the nature and prevalence of poverty in Nigeria, but they are not all easily accessible by civil-society groups.
Pyke, Toni, Ali-Akpajiak, Sofo C A
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Measuring progress towards global poverty goals: Challenges and lessons from southern Africa [PDF]
This paper draws on the work in Lesotho and Namibia of tracking progress towards cutting poverty in half by 2015, which is the key poverty target of the Millennium Development Goals. The paper serves at least two purposes.
Levine, Sebastian
core +1 more source
Orphanhood, Poverty and the Care Dilemma: Review of Global Policy Trends
Social Work and Society, 2009 The care and protection of children experiencing orphanhood presents a major child-care policy challenge. This paper draws on a review of the literature to document divergent conceptualizations of orphanhood, how the hurdles for the care of orphans ...
Tatek Abebe
doaj +2 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Cointegration growth, poverty and inequality in Sudan [PDF]
This analytical review explores the links between growth, poverty and inequality in Sudan for the period 1956-2003. This paper build upon different models to investigate empirically the relationship between economic growth – as measured by GDP per capita
Mohamed Hassan, Hisham
core +1 more source
Soil map density and a nation's wealth and income [PDF]
, 2008 Little effort has been made to link soil mapping and soil data density to a nation’s welfare. Soil map density in 31 European countries and 44 low and middle income countries is linked to Gross Domestic Product (GDP) per capita and the number of soil ...
Hartemink, A.E.
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