Results 171 to 180 of about 34,360 (258)

Determinants of malaria prevalence among children under 5 years of age in 17 sub-Saharan African countries: insights from Malaria Indicator Surveys. [PDF]

Glob Health Action
Kassie AT, Bazezew AM, Tamir TT, Tekeba B, Zeleke GA, Mekonen EG, Endalew HL, Wassie M, Zegeye AF.   +8 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Scabies Outbreak in Pediatric Populations of Bangladesh: A Perspective on Therapeutic Management, Risk Factors, and Public Health Implications. [PDF]

Health Sci Rep
Hossain H, Muktadir MA, Binte Sayeed SS, Ahmed S, Ali MH, Brishty KA, Chowdhury MSR, Rahman MM.   +7 more
europepmc   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Rats exposed to a low resource environment in early life display sex differences in blood pressure, autonomic activity, and brain and kidney pro-inflammatory markers during adulthood. [PDF]

Biol Sex Differ
Smith J, Smith S, Jones K, Castillo A, Bolton JL, Howard A, Colon-Perez L, Femi-Ogunyemi F, Burkes A, Cunningham M.   +9 more
europepmc   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Establishing research and translation priorities and care pathways for families where a parent lives with mental ill health. [PDF]

PLOS Ment Health
Maybery D, Davidson G, Grant A, Piché G, Yates S, Ruud T, Dunkley-Smith A, Banfield M, Bibb J, Jazayeri D, Palmer VJ.   +10 more
europepmc   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Cancer: a looming public health crisis in Africa-a call to accelerate equitable access to medicines. [PDF]

Oncologist
Anorlu RI, Amaeshi LC, Okunade KS, Okunowo AA, Ohazurike EO, Soibi Harry AP, Duru ON, Murphy A.   +7 more
europepmc   +1 more source