Results 161 to 170 of about 2,599,250 (332)

The impact of roads on poverty reduction : a case study of Cameroon [PDF]

open access: yes
Many investments in infrastructure are built on the belief that they will ineluctably lead to poverty reduction and income generation. This has entailed massive aid-financed projects in roads in developing countries.
Gachassin, Marie   +2 more
core  

Half Measures: The ANC's Unemployment and Poverty Reduction Goals [PDF]

open access: yes, 2004
Simulations suggest that under the most optimistic conditions, halving the official rate of unemployment would require 3.7 million jobs to be created between 2004 and 2014. Halving the number of expanded unemployed under pessimistic assumptions about the
Meth, Charles
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

The forest-hydrology-poverty nexus in Central America : An heuristic analysis [PDF]

open access: yes
A"forest-hydrology-poverty nexus"hypothesis asserts that deforestation in poor upland areas simultaneously threatens biodiversity and increases the incidence of flooding, sedimentation, and other damaging hydrological processes.
Nelson, Andrew, Chomitz, Kenneth M.
core  

Child poverty map of the UK [January 2012] [PDF]

open access: yes, 2012
Child poverty map of the UK [January ...
Jacqueline Beckhelling (7153706)   +1 more
core  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

open access: yesFEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo   +7 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

What helps households with children in leaving poverty? Evidence from Spain [PDF]

open access: yes
In this paper we analyse the distinct effectiveness of demographic, labour market and welfare state transfers events in promoting exits from deprivation for childbearing households in Spain, a Southern European Country with high and persistent child ...
Olga Cantó   +2 more
core  

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

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