Results 81 to 90 of about 34,360 (258)
Choropleth map legend design for visualizing community health disparities
International Journal of Health Geographics, 2009 Background Disparities in health outcomes across communities are a central concern in public health and epidemiology. Health disparities research often links differences in health outcomes to other social factors like income.
Cromley Ellen K, Cromley Robert G
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Orphanhood, Poverty and the Care Dilemma: Review of Global Policy Trends
Social Work and Society, 2009 The care and protection of children experiencing orphanhood presents a major child-care policy challenge. This paper draws on a review of the literature to document divergent conceptualizations of orphanhood, how the hurdles for the care of orphans ...
Tatek Abebe
doaj +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
County-Level Poverty Evaluation Using Machine Learning, Nighttime Light, and Geospatial Data
Remote SensingThe accurate and timely acquisition of poverty information within a specific region is crucial for formulating effective development policies. Nighttime light (NL) remote sensing data and geospatial information provide the means for conducting precise ...
Xiaoqian Zheng +3 more
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Mapping Subnational Poverty in Zambia [PDF]
, 2015 Many challenges were identified during the Fifth National Development Plan (FNDP) in Zambia. To address these challenges and realize pro-poor growth, the Sixth National Development Plan (SNDP) was set in motion. The SNDP, which covers 2011 to 2015, was designed to accomplish three goals: to accelerate infrastructure development (roads, bridges, air ...
Alejandro de la Fuente +2 more
openaire +2 more sources
Triple Helix in the Poverty Reduction Policy Based on Community Empowerment in Semarang City
E3S Web of Conferences, 2018 The policy of poverty reduction based on empowerment issued into Local Regulation of Semarang City No. 12 in 2016 will be hard to implement without stakeholders.
Amni Zarkasyi Rahman, Diyah Novitasari
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source