Results 81 to 90 of about 269,582 (254)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
India’s water future to 2025-2050: Business-as-usual scenario and deviations [PDF]
Poverty / Mapping/ Water demand / Water supply / Population growth / Crop production / Crop yield / Groundwater irrigation / Food ...
Amarasinghe, Upali +3 more
core
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Transfer Learning from Deep Features for Remote Sensing and Poverty Mapping
, 2016 The lack of reliable data in developing countries is a major obstacle to sustainable development, food security, and disaster relief. Poverty data, for example, is typically scarce, sparse in coverage, and labor-intensive to obtain.
Burke, Marshall +4 more
core +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Mapping Poverty and Well-Being Through Natural Language Processing
Revista de Estudios SocialesPoverty and well-being indexes encompass dimensions that capture meaningful aspects of life worth measuring. These dimensions reflect people’s concerns and priorities, offering insight into their lived experiences.
Guberney Muñetón-Santa +2 more
doaj +1 more source
Assessing the geographic impact of higher food prices in Guinea [PDF]
Telling a policy maker that poverty will increase due to the recent increase in food prices is not very useful; telling the policy makers where the impact is likely to be larger is better, so that measures to cope with the impact of the crisis can be ...
Coulombe, Harold, Wodon, Quentin
core
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Poverty mapping with aggregate census data [PDF]
Spatially disaggregated maps of the incidence of poverty can be constructed by combining household survey data and census data. In some cases, however, statistical authorities are reluctant, for reasons of confidentiality, to release household-level ...
Baulch, Bob, Minot, Nicholas
core