Results 121 to 130 of about 3,813,329 (294)
, 2009 This report focuses on the relative poverty rate of Irish elderly, and aims to study the connection between potential changes to the state pension system and such poverty rates. The majority of Irish elderly depend in fact almost exclusively on the state
O’Donoghue, Cathal, Baroni, Elisa
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Association of Race and Poverty Status With DNA Methylation-Based Age.
JAMA Netw Open, 2023 Shen B +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Tackling poverty comprehensively: effectively tackling social exclusion: the Irish experience
, 1999 We,in Ireland, are now at a key moment in our history. We are faced by a period of extraordinarily rapid and largely positive political, economic, social, cultural and demographic change. This poses us with a major choice or challenge. Will we use the
Frazer, Hugh
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Towards a policy for combating poverty amongst women
, 1990 This policy document on women and poverty is the culmination of three years of work on the issue by the Agency. It draws on both the experience of local women's projects in marginalised communities and research and analysis which the Agency has ...
Combat Poverty Agency (CPA)
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Status and determinants of multi-dimensional poverty in Wolaita Sodo Town, southern Ethiopia
Journal of Agriculture and Food ResearchMulti-dimensional poverty remains a staggering problem in Ethiopia, especially among urban households. Despite its widespread recognition, there is a dearth of comprehensive studies that specifically examine the status and determinants of multi ...
Eshetu Esrael +5 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Report on combat poverty led consultation process for people living in vulnerable circumstances
, 2006 In the context of its role in supporting consultation on the National Action Plan against Poverty and Social Inclusion 2006-2008 (NAP/Inclusion), the Combat Poverty Agency undertook to organise a consultation process focusing on the poverty issues ...
Combat Poverty Agency
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source