Results 71 to 80 of about 359,584 (301)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Day-Ahead Dispatch Model of Electro-Thermal Integrated Energy System with Power to Gas Function

Applied Sciences, 2017
The application of power to gas (P2G) provides a new way to absorb intermittent renewable energy generation, which improves the efficiency of renewable energy utilization and provides the necessary flexibility for operating the integrated energy system ...
Deyou Yang, Yufei Xi, Guowei Cai
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Do Renewable Energy Policies Reduce Carbon Emissions? On Caps and Intra-Jurisdictional Leakage [PDF]

, 2015
Climate policies overlapping a cap-and-trade scheme are generally considered not to change domestic emissions. In a two-sector general equilibrium model where only one sector is covered by a cap, we find that such policies do have a net impact on carbon ...
Jarke, Johannes, Perino, Grischa
core  

Association of Corticospinal Tract Asymmetry With Ambulatory Ability After Intracerebral Hemorrhage

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ambulatory ability after intracerebral hemorrhage (ICH) is important to patients. We tested whether asymmetry between ipsi‐ and contra‐lesional corticospinal tracts (CSTs) assessed by diffusion tensor imaging (DTI) is associated with post‐ICH ambulation.
Yasmin N. Aziz, Carl D. Langefeld, Mary E. Comeau, Miranda C. Marion, Tyler P. Behymer, Lee A. Gilkerson, Padmini Sekar, Weihong Yuan, Vivek Khandwala, Brady J. Williamson, Thomas Maloney, Achala Vagal, Pierce Boyne, Kari Dunning, Matthew L. Flaherty, Steven J. Kittner, Prachi Mehndiratta, Gunjan Y. Parikh, Michael L. James, David Roh, Fernando D. Testai, Farhaan S. Vahidy, James Thornton, Ranjit Bagga, Daniel Woo, Stacie L. Demel   +25 more
wiley   +1 more source

Thermal Characterization and Lifetime Prediction of LED Boards for SSL Lamp [PDF]

, 2013
This work presents a detailed 3-D thermo-mechanical modelling of two LED board technologies to compare their performance. LED board are considered to be used in high power 800 lumen retrofit SSL (Solid State Lighting) lamp.
Formanek, J., Jakovenko, J.
core   +1 more source

Provision of frequency containment reserves with batteries and power-to-heat

2017 IEEE Manchester PowerTech, 2017
Frequency Containment Reserves (FCR), previously referred to as primary reserves, are an important component for the safe operation of the Continental Europe grid. The growing share of renewables represents a forthcoming challenge since FCR are generally provided by synchronous generators.
Jomaux, Julien, Mercier, Thomas, De Jaeger, Emmanuel, 2017 IEEE Manchester PowerTech   +3 more
openaire   +2 more sources

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Locating a bioenergy facility using a hybrid optimization method [PDF]

, 2010
In this paper, the optimum location of a bioenergy generation facility for district energy applications is sought. A bioenergy facility usually belongs to a wider system, therefore a holistic approach is adopted to define the location that optimizes the ...
Rentizelas, Athanasios A., Tatsiopoulos, Ilias P.   +1 more
core   +1 more source

Meeting Global Cooling Demand with Photovoltaics during the 21st Century

, 2019
Space conditioning, and cooling in particular, is a key factor in human productivity and well-being across the globe. During the 21st century, global cooling demand is expected to grow significantly due to the increase in wealth and population in sunny ...
Buonassisi, Tonio, Laine, Hannu S., Looney, Erin E., Peters, Ian Marius, Salpakari, Jyri, Savin, Hele   +5 more
core   +2 more sources