Results 61 to 70 of about 6,815,632 (371)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Injection Locking in Switching Power Amplifiers
IEEE Access, 2020 In this work, injection locking in switching power amplifiers (PAs) is studied. Traditionally, injection-locked PAs (ILPAs) have supported phase modulation, with injection locking used primarily to improve the power-added efficiency by reducing the power
Amit Kumar Mishra +2 more
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
New methodology for modeling, design and implementation of RF power amplifiers
Journal of Microwaves, Optoelectronics and Electromagnetic ApplicationsThis work presents a new methodology for modeling, design and implementation of power amplifiers in different technologies. As result of comparison, a flowchart with a new methodology is proposed which can be useful for the designer to design and ...
Guillermo Rafael-Valdivia +1 more
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
IEEE Access, 2018 A novel dual-transformation simplified real frequency technique is proposed in this paper to synthesize a broadband Doherty power amplifier (DPA). The proposed method can realize the co-design of the carrier and peaking output matching networks to ...
Fan Meng +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Effects of Non-Ideal Pre-Distorter High Power Amplifiers in WCDMA Using Multi-User Detectors
Iranian Journal of Electrical and Electronic Engineering, 2010 Wide band code division multiple access (WCDMA) signals, transmitted by the base station high power amplifiers (HPAs), show high peak to average power ratios (PAPR), which results in nonlinear distortions. In this paper, using computer simulations effect
S. Ghavami, B. Abolhassani
doaj
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source