Results 121 to 130 of about 9,414,122 (340)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Positive childhood experiences and burnout among medical students: the role of adaptive emotion regulation as a mediator

Frontiers in Psychology
Burnout is a state of chronic exhaustion caused by excessive stress. Medical trainees are highly vulnerable to burnout, which can negatively affect their well-being. Empirical evidence from Bethell et al.
Rachel Lloyd, Tina Izad, Michael Nazmifar, Lauren Walkon, Changiz Mohiyeddini   +4 more
doaj   +1 more source

Bayesian methods for multiple mediators: Relating principal stratification and causal mediation in the analysis of power plant emission controls [PDF]

, 2019
Chanmin Kim, Michael J. Daniels, Joseph W. Hogan, Christine Choirat, Corwin Zigler   +4 more
openalex   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

GSD-SSR: an integrated framework for power analysis in IRB proposals using group sequential design and sample size re-estimation

Frontiers in Applied Mathematics and Statistics
Accurate sample size estimation is a cornerstone of successful Institutional Review Board (IRB) proposals, as it establishes the feasibility of clinical studies and ensures they are sufficiently powered to detect meaningful effects.
Yuxi Zhu, Yuxi Zhu, Shi Du, Peihe Xia, Peihe Xia   +4 more
doaj   +1 more source

Determination of Weibull Parameters by Different Numerical Methods and Analysis of Wind Power Density in Osmaniye, Turkey [PDF]

, 2017
Yusuf Alper Kaplan
openalex   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Side-Channel Attack on ARADI in Non-Profiling Scenarios

IEEE Access
ARADI is a low-latency block cipher introduced by the NSA (National Security Agency), designed with consideration for applications in memory encryption.
Donggeun Kwon, Seokhie Hong
doaj   +1 more source

Performance Analysis of a Scalable DC Microgrid Offering Solar Power Based Energy Access and Efficient Control for Domestic Loads [PDF]

, 2018
Abu Shahir Md. Khalid Hasan, Dhiman Chowdhury, Mohammad Ziaur Rahman Khan   +2 more
openalex   +1 more source

COST-VOLUME-PROFIT ANALYSIS OF POWER SECTOR INDUSTRY IN BANGLADESH: A STUDY ON BARAKA POWER LIMITED

, 2021
Tahrima Chowdhury Jannath
openalex   +1 more source