Power Analysis for Moderator Effects in Longitudinal Cluster Randomized Designs. [PDF]
Educ Psychol Meas, 2023 Li W, Konstantopoulos S.
europepmc +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Toward Power Analysis for Partial Least Squares-Based Methods. [PDF]
Biom JAndreella A +3 more
europepmc +1 more source
Power analysis of longitudinal studies with piecewise linear growth and attrition. [PDF]
Behav Res Methods, 2022 Moerbeek M.
europepmc +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Correction: Power analysis for personal light exposure measurements and interventions. [PDF]
PLoS OneZauner J, Udovicic L, Spitschan M.
europepmc +1 more source
Power analysis for idiographic (within-subject) clinical trials: Implications for treatments of rare conditions and precision medicine. [PDF]
Behav Res Methods, 2023 Tueller S +7 more
europepmc +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
MiSDEED: a synthetic data engine for microbiome study power analysis and study design. [PDF]
Bioinform Adv, 2022 Chlenski P, Hsu M, Pe'er I.
europepmc +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source