Results 141 to 150 of about 1,129,017 (245)

Geospatial assessment of habitat degradation and climate impacts on migratory crane habitat in Pakistan's Wetland ecosystems. [PDF]

Sci Rep
Suliman M, Hongxue L, Khalid F, Qingming W, Xueying S, Hussain M, Hongfei Z, Ahmad T, Ullah I, Ullah S.   +9 more
europepmc   +1 more source

PDZK1‐ULK1 Axis Triggers Lipophagy to Inhibit Tumor Progression and Sunitinib Resistance in Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reveals that PDZK1 loss impairs ULK1‐mediated lipophagy, driving lipid droplet accumulation and sunitinib resistance in clear cell renal cell carcinoma. PDZK1 inhibits LEF1 nuclear translocation, enhancing ULK1 transcription. Pharmacological ULK1 activation resensitizes resistant tumors to sunitinib.
Xuan Qi, Yu Guo, Yumeng Yang, Haibo Wang, Xiaomei Yang, Ran Song, Qiong Qin, Yan Zhang, Meihan Hu, Haixing Zhou, Duiping Feng, Junqi He   +11 more
wiley   +1 more source

CFD-enabled sustainable design and manufacturing of cooling fan for unmanned helicopter. [PDF]

Sci Rep
Si L, Liu Z, Xiao N, Zhang Y, Liu Y, Deng S, Li Y, Yang H, Zhang X, Fu G, Choi JP.   +10 more
europepmc   +1 more source

Coal Conservation and Electric Power Supply [PDF]

Nature, 1918
openaire   +1 more source

Time‐Resolved SAXS Reveals Distinct Millisecond Metal‐Induced Conformational Dynamics of Monomeric α‐Synuclein

Advanced Science, EarlyView.
Time‐resolved SAXS reveals how physiologically relevant metal ions shape the earliest conformational responses of monomeric α‐synuclein. Fe3+ induces rapid compaction, Cu2+ generates heterogeneous and partially folded ensembles, while Mn2+ and Zn2+ cause only modest changes.
Rebecca Sternke‐Hoffmann, Miriam Dos Santos Pinto, Xue Wang, Jinghui Luo   +3 more
wiley   +1 more source

The SPA-cube framework: An integrated approach for analysing power dynamics in environmental governance. [PDF]

MethodsX
Sahide MAK, Siswandi S, Sirimorok N, Fisher MR, Wong GY, Brockhaus M.   +5 more
europepmc   +1 more source

Integrated Single‐Cell and Spatial Transcriptomics Reveal Cell‐Type‐Specific Immune Regulatory Networks in Maize Responding to Southern Corn Rust

Advanced Science, EarlyView.
By integrating single‐nuclei and spatial transcriptomics, this study presents a stereoscopic landscape of maize leaf to Puccinia polysora infection. Epidermal and mesophyll cells initiate primary defenses via RLPs/RLKs and jasmonic acid signaling. Cell‐cell communication analyses further reveal the underlying the dynamics of the underlying immune ...
Qiongqiong Wang, Xinyan Sun, Yingchao Sun, Zeqiang Cheng, Zixiang Cheng, Shengbo Han, Ying Feng, Wenbo Yang, Huimin Li, Meichen Zhu, Xiaoling Wu, Jinghua Zhang, Jihua Tang, Honglian Li, Yanyong Cao, Canxing Duan, Yan Shi   +16 more
wiley   +1 more source

Changing the fate of rangelands through behavioral nudges for sustainable land use and management using an extended theory of planned behavior. [PDF]

Sci Rep
Valizadeh N, Bazrafkan K, Haji L, Karami S, Azadi H, Alinaghizadeh M.   +5 more
europepmc   +1 more source

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

Advanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang, Yuli Zhang, Zixin Kang, Jiayun Xiong, Ronghua Yang, Kang Ning   +5 more
wiley   +1 more source

Exploring the regulatory potential of RNA structures in 202 cyanobacterial genomes. [PDF]

Nucleic Acids Res
Geissler AS, Carrasquer-Alvarez E, Anthon C, Frigaard NU, Gorodkin J, Seemann SE.   +5 more
europepmc   +1 more source