Results 41 to 50 of about 1,133,853 (295)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
AC fault ride through control strategy on inverter side of hybrid HVDC transmission systems
Hybrid high-voltage direct current (HVDC) transmission systems employ a new type of HVDC transmission topology that combines the advantages of the line-commutated converter system and the voltage-source converter system.
Zexin Zhou +6 more
doaj +1 more source
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Boundary-induced heterogeneous absorbing states [PDF]
We study two different types of systems with many absorbing states (with and without a conservation law) and scrutinize the effect of walls/boundaries (either absorbing or reflecting) into them.
Joaquín Marro +4 more
core +2 more sources
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
In VSC-HVDC system for new energy island, surplus power consumption in the system during fault ride-through (FRT) is achieved by employing grouped AC energy-dissipating resistors of equal capacity. However, the presence of an excessively powered resistor
FENG Yanbo +6 more
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Inverter-based resources (IBRs), such as wind and photovoltaic generation, are characterized by low capacity and extensive distribution, which can exacerbate the weak properties of power systems.
Lin Yu +5 more
doaj +1 more source
Fighting Through Community Participation Based on Vegetative Conservation Approach of Wonogiri Reservoir Sedimentation in Sub - Watershed of Keduang [PDF]
Humans are the main trigger factors causes of sedimentation. It’s happened because of the farming and cultivation system that is not based on the principles of sustainable development. These human activities causes in damage to the environment in the
Maridi, +3 more
core
Quasilocal Conservation Laws: Why We Need Them
We argue that conservation laws based on the local matter-only stress-energy-momentum tensor (characterized by energy and momentum per unit volume) cannot adequately explain a wide variety of even very simple physical phenomena because they fail to ...
Bell J S +10 more
core +1 more source

