Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Wireless scheduling with power control [PDF]
We consider the scheduling of arbitrary wireless links in the physical model of interference to minimize the time for satisfying all requests. We study here the combined problem of scheduling and power control, where we seek both an assignment of power settings and a partition of the links so that each set satisfies the signal-to-interference-plus ...
openaire +5 more sources
Liver organoids: modelling complexity in homeostasis and disease
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Control engineering : control system power and grounding better practice /
Control system power and grounding is possibly the single most important element to ensure a control system doesn't experience unidentified 'gremlins' throughout its life.
Hope, Roger. +2 more
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Grid Connection improvements by control strategy selection for wave energy converters [PDF]
Publisher Copyright: © 2011, European Association for the Development of Renewable Energy, Environment and Power Quality (EA4EPQ). All rights reserved.In this paper a wave-to-wire approach to model the exploitation of ocean energy by point absorbers in ...
Martin, J. L. +9 more
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
A real-time control system architecture for industrial power amplifiers
Power amplifiers are a highly important component in a range of industrial applications, such as, servo-drives, magnetic resonance imaging, energy systems, and audio.
Lazar, M Mircea +7 more
core
Multilevel İnverters control methods and advanced power electronic applications
Multilevel Inverters: Control Methods and Power Electronics Applications provides a suite of powerful control methods for conventional and emerging inverter topologies instrumentalized in power electronics applications.
Kabalcı, Ersan
core +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source

