Results 41 to 50 of about 10,991 (266)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Recovery strategy of distribution network based on dynamic island rescue under extreme weather

IET Energy Systems Integration
The frequent occurrence of various extreme weather has a great influence on the normal and stable operation of the distribution network. In order to minimise the large‐scale power loss of the distribution network caused by extreme weather, considering ...
Xinrui Liu, Qingkun Meng, Rui Wang, Chaoyu Dong, Qiuye Sun   +4 more
doaj   +1 more source

Estimation of Vulnerable Areas to Faults Caused by Tree Vegetation in Power Distribution Systems

IEEE Access
Faults in power distribution feeders cause damage to power utilities due to the deterioration of reliability and power quality indexes and the displacement of field maintenance teams to replace or repair power grid equipment. Additionally, consumer units
Andreia S. Santos, Lucas Teles Faria, Leticia S. Boschi, Mara Lucia M. Lopes, Carlos R. Minussi   +4 more
doaj   +1 more source

Power supply risk assessment method for relay protection system faults

Archives of Electrical Engineering, 2016
The influence and the potential risk due to hidden faults of a relay protection system on power supply in distribution systems are paid more and more attention to.
Tuyou Si, Jiekang Wu, Weideng Yuan, Anan Du   +3 more
doaj   +1 more source

A two‐stage service restoration method for electric power distribution systems

IET Smart Grid, 2021
Improving the reliability of power distribution systems is critically important for both utilities and customers. This calls for an efficient service restoration module within a distribution management system to support the implementation of self‐healing
Shiva Poudel, Anamika Dubey
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Fault analysis and prediction of power distribution networks on 11kV Feeders: A case study of Eleweeran and Poly Road 11kV Feeders, Abeokuta

MANAS: Journal of Engineering, 2020
Distribution system, a vital link between the bulk power system and end users, accounts for 90% of power service interruptions. This study analyses faults occurring on power distribution network using Eleweeran and Poly Road 11 kV feeders in Abeokuta as ...
Ayodeji Okubanjo, Ajibola Oyedejı, Grace Olasunkanmı   +2 more
doaj  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source