Results 91 to 100 of about 25,369,668 (289)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Novel Resonant DC Breaker with Capacitor Self-Charging by Controllable Injection Energy and Internal Overvoltage Suppression

Energies
With the rapid development of DC grids, resonant DC circuit breakers (RDCBs) have become critical for fault isolation. However, existing RDCBs often suffer from severe energy mismatches, and components, including mechanical switches, resonant capacitors,
Yumin Zhang, Xingning Han, Weijie Wen, Bin Li, Zhicheng Zhang   +4 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Multi-Parameter Sensitivity Analysis and Engineering Configuration Optimization Strategies for Sheath Protectors in 220 kV Cable Systems Based on Overvoltage Characteristic Analysis

Energies
This paper focuses on 220 kV cable sheath overvoltage caused by three typical operating conditions: harmonics, short-circuits, and lightning strikes. A sheath voltage simulation model on the 220 kV side is developed in PSCAD.
Xiaoyan Ji, Yong Liu, Qiran Li
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

An optimal expansion planning of electric distribution network incorporating health index and non-network solutions

CSEE Journal of Power and Energy Systems, 2020
Limei Zhou, Wanxing Sheng, Wei Liu, Zhao Ma   +3 more
doaj   +1 more source

The effects of priming intermittent theta-burst stimulation on phase-amplitude coupling and its directionality in Alzheimer’s disease rats

Brain-Apparatus Communication
Aim Intermittent theta burst stimulation (iTBS) shows promise in alleviating cognitive dysfunction in neurodegenerative diseases. Pre-treatment with iTBS could potentially modulate the threshold of synaptic plasticity, which may enhanc the facilitative ...
Miaomiao Guo, Biao Zhang, Yingxue Zhang, Haodi Zhai, Tian Wang, Shanshan Li, Mengfan Li, Guizhi Xu, Pan Wang, Yong Ji   +9 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

A Two-Layer User Energy Management Strategy for Virtual Power Plants Based on HG-Multi-Agent Reinforcement Learning

Applied Sciences
Household loads are becoming dominant in virtual power plants (VPP). However, their dispatch potential has not yet been explored due to the lack of detailed user power management.
Sen Tian, Qian Xiao, Tianxiang Li, Zibo Wang, Ji Qiao, Hong Zhu, Wenlu Ji   +6 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source