Results 81 to 90 of about 10,915 (306)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Implementation of exact and approximate adder based divider for error resilient applications

Discover Computing
Approximate computing has emerged as a promising paradigm for error-tolerant applications, enabling power-efficient designs with minimal compromise in output quality.
Veerabadra Chary Rasoju, Anil Kumar Uppugunduru, Abhay Shriram, Sreehari Veeramachaneni, Syed Ershad Ahmed   +4 more
doaj   +1 more source

Action of Divided Differences on Modified Powers

Advances in Applied Mathematics, 1999
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A Compact and Low-Loss Microstrip Filtered Power Divider for Millimeter-Wave Applications

IEEE Access
This paper describes the filtered power divider design using microstrip lines architecture. A transmission zero is generated through two resonant cavities to improve selectivity and isolation.
Ming-An Chung, Chia-Wei Lin, Yu-Hsun Chen   +2 more
doaj   +1 more source

Wideband and Compact Wilkinson Power Divider Utilizing Series Delta-Stub and Folded Stepped-Impedance Transmission Line [PDF]

Radioengineering, 2018
In this paper, a Wilkinson power divider is modified using four-series delta-stub and folded stepped-impedance transmission line (FSITL) in order to achieve a reduced circuit size of 84% and fractional bandwidth of 116%.
N. Al-Areqi, K. Y. You, C. Y. Lee, N. H. Khamis, M. N. Dimon   +4 more
doaj  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Coupled-Resonator 3-dB Power Divider [PDF]

, 2010
This paper presents a technique to synthesise a coupled resonator power divider. . The design of the proposed power divider is based on coupling matrix optimization for multiple coupled resonators with multiple outputs.
Skaik, Talal, Huang, Frederick, Skaik, Talal F., Lancaster, Michael   +3 more
core  

Compact wide-band gysel power divider

, 2022
A compact and wideband Gysel power divider is proposed in this study. The design steps on a widely available low-cost FR-4 substrate are presented. The design is simulated with a Method-of-Moments based 2.5D EM simulator and verified with measurement ...
Tekin, Harun, Savcı, Hüseyin Şerif, Elsherbeni, Atef Z.   +2 more
core   +1 more source