Results 51 to 60 of about 467,553 (264)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
tripleC: Communication, Capitalism & CritiqueThis article examines the transformative potential of community radio (CR) in facilitating social change. Using a case study of Khwezi Community Radio (KR) in South Africa (SA), the study draws on vignette-based analysis informed by content analysis of ...
Sibonile Linda Khumalo
doaj +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
EcosphereA positive correlation between wealth and biodiversity within cities is a commonly documented phenomenon in urban ecology that has come to be labeled as the “luxury effect.” We contend that both this language and this framing restrict our understanding ...
Renata Poulton Kamakura +3 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
People-conscious leadership: Strategic and tactical strengths of Pharisees in early Christianity
Verbum et EcclesiaThe Pharisees are frequently depicted in the New Testament as adversaries of early Christians. However, this narrow portrayal fails to capture their broader historical significance and the substantial role they played in shaping Jewish religious life ...
Azwihangwisi E. Bvumbi
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Global Social Challenges JournalThis article seeks to inform the quest to decolonize research collaborations between the North (N) and South (S) that started as early as the 1970s, given the prevailing power asymmetries that continue to hinder equitable collaboration.
Mariah Ngutu +4 more
doaj +1 more source
Marine protected areas as a tool for environmental justice
Frontiers in Marine ScienceOverfishing, destructive industrial practices, and climate change are the biggest drivers of biodiversity loss in the ocean. Marine Protected Areas (MPAs), including through nature conservation initiatives like “30x30” and “America the Beautiful,” can be
Anupa Asokan
doaj +1 more source