Results 41 to 50 of about 24,286 (311)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The quasi-continuous exhaust regime in JET

Nuclear Fusion
The quasi-continuous exhaust (QCE) regime is a regime that is naturally type-I ELM-free. It combines the high density at the plasma edge needed for power exhaust with the high normalised energy confinement typical for H-mode operation.
M. Faitsch, M. Dunne, E. Lerche, P. Lomas, I. Balboa, P. Bilkova, P. Bohm, A. Kappatou, D. Kos, B. Labit, S. Menmuir, O. Sauter, S. Silburn, E.R. Solano, H.J. Sun, A. Tookey, E. Viezzer, U. Stroth, JET Contributors, the EUROfusion Tokamak Exploitation Team   +19 more
doaj   +1 more source

Epistemic Exhaustion and the Retention of Power

SSRN Electronic Journal, 2023
AbstractEpistemic exhaustion is cognitive fatigue generated by efforts to determine, retain, or communicate what one believes under conditions that make doing so especially taxing. I argue that the creation and maintenance of epistemic exhaustion is a tool that the socially and politically powerful can and do use in order to retain power.
openaire   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Exhaust heat harvesting of automotive engine using thermoelectric generation technology

Energy Conversion and Management: X, 2023
Exhaust heat recovery from internal combustion engines is growing interest to reduce fuel consumption, increase the efficiency and consequently, reduce the environmental pollution and global warming.
Md. Asaduzzaman, Md. Hasan Ali, Nahyan Ahnaf Pratik, Nafisa Lubaba   +3 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Predictive power-sharing scaling law in double-null L-mode plasmas

Nuclear Fusion
The physical mechanisms regulating the power sharing at the outer targets of L-mode double-null (DN) configurations are investigated using nonlinear, flux-driven, three-dimensional two-fluid simulations.
K. Lim, P. Ricci, L. Stenger, B. De Lucca, G. Durr-Legoupil-Nicoud, O. Février, C. Theiler, K. Verhaegh   +7 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

COMPASS Upgrade: a high-field tokamak for ITER- and DEMO-relevant research

Nuclear Fusion
To achieve their goals, future thermonuclear reactors such as ITER and DEMO are expected to operate plasmas with a high magnetic field, triangularity and confinement. To address the corresponding challenges, the concept of the high-field ( $B_{\textrm{T}}
M. Komm, F. Jaulmes, O. Grover, M. Peterka, J. Seidl, M. Imrisek, S. Saarelma, P. Snyder, M. Sos, J. Caloud, I. Borodkina, O. Shyshkin, J. Cecrdle, M. Farnik, J. Gerardin, L. Kripner, R. Dejarnac, J. Horacek, S. Lukes, J. Havlicek, D. Tskhakaya, M. Hron, R. Panek, P. Vondracek, V. Weinzettl, the COMPASS Upgrade Team   +25 more
doaj   +1 more source

Carbon dioxide removal from power plant exhausts

Environment International, 1979
Abstract The various options for removing carbon dioxide (CO 2 ) from power plant exhaust gases are reviewed. An absorption-stripping system using amine solutions and dissolution of gaseous CO 2 into deep ocean waters is a feasible choice with a marginal cost of electricity below 15%.
C. Mustacchi, P. Armenante, V. Cena
openaire   +1 more source