Results 61 to 70 of about 24,106 (263)

The quasi-continuous exhaust regime in JET

Nuclear Fusion
The quasi-continuous exhaust (QCE) regime is a regime that is naturally type-I ELM-free. It combines the high density at the plasma edge needed for power exhaust with the high normalised energy confinement typical for H-mode operation.
M. Faitsch, M. Dunne, E. Lerche, P. Lomas, I. Balboa, P. Bilkova, P. Bohm, A. Kappatou, D. Kos, B. Labit, S. Menmuir, O. Sauter, S. Silburn, E.R. Solano, H.J. Sun, A. Tookey, E. Viezzer, U. Stroth, JET Contributors, the EUROfusion Tokamak Exploitation Team   +19 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Market Power in the Global Economy: The Exhaustion and Protection of Intellectual Property [PDF]

The Economic Journal, 2012
This paper analyzes economic linkages between the exhaustion and protection of intellectual property. We consider a North-South model, where a …rm that enjoys monopoly status in the North by virtue of an intellectual property right (IPR) –such as a patent or a trademark –has the incentive to price discriminate internationally because Northern consumers
openaire   +3 more sources

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Cross-code comparison of the edge codes SOLPS-ITER, SOLEDGE2D and UEDGE in modelling a high-power neon-seeded scenario in the DTT

Nuclear Fusion
In this work, we cross-compare the state-of-the-art edge plasma codes SOLPS-ITER, SOLEDGE2D, and UEDGE in a reactor-relevant neon-seeded Divertor Tokamak Test scenario at nominal power, extending the simplified test-bed of Moscheni et al (2022 Nucl ...
M. Moscheni, M. Wigram, H. Wu, C. Meineri, C. Carati, E. De Marchi, M. Greenwald, P. Innocente, B. LaBombard, F. Subba, R. Zanino   +10 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Advancing SOLPS-ITER validation with TCV L-mode discharges

Nuclear Fusion
This work advances the quantitative validation of SOLPS-ITER against Tokamak à Configuration Variable ( TCV ) ohmic L-mode discharges. It shows that the treatment of the ion parallel heat flux limiter and the assumptions adopted for chemical sputtering ...
E. Tonello, M. Carpita, S. Donzella, R. Ducker, G. Durr-Legoupil-Nicoud, B.P. Duval, O. Février, D. Hamm, K. Lee, M. Marin, D. Mykytchuk, M. Pedrini, A. Perek, H. Reimerdes, C. Theiler, M. Zurita, M. Bernert, N. Fedorczak, S. Henderson, E. Tsitrone, N. Vianello, the TCV Team, the EUROfusion Tokamak Exploitation Team   +22 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Radiative divertor detachment and impurity transport with nitrogen and neon seeding in KSTAR H-mode plasmas

Nuclear Fusion
Achieving core-edge compatible divertor detachment is a critical requirement for stable operation in future fusion devices. This study compares nitrogen and neon seeding in KSTAR H-mode plasmas with carbon walls, combining experiments and SOLPS-ITER ...
Junghoo Hwang, Hyungho Lee, Richard A. Pitts, Andrei Pshenov, Jae-Sun Park, Yoon Seong Han, June-Woo Juhn, Matthias Bernert, Jun-Gyo Bak, Suk-Ho Hong, Wonho Choe   +10 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source