Results 71 to 80 of about 24,286 (311)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Exhaust Gas Recirculation as a Major Technique Designed to Reduce NOх Emissions from Marine Diesel Engines

Naše More (Dubrovnik), 2019
The study objective is to identify to what extent the recirculation of exhaust gas from a low-speed marine diesel engine affects environmental, economic and power-related parameters in engine operation.
Oleksiy Andriiovych Kuropyatnyk, Sergii Victorovych Sagin   +1 more
doaj   +1 more source

Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and One‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study

Arthritis Care &Research, Accepted Article.
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension‐phase). During part 1, three doses were assessed in two weight groups (Group A/B: ≥30–60 kg/≥10–<
Fabrizio De Benedetti, Inmaculada C. Penadés, Irina Nikishina, Ivan Foeldvari, Alberto J. Spindler, Anna Kozlova, Nadina Rubio‐Pérez, Pierre Quartier, Zbigniew Żuber, Raul Barria, Daniel Clemente, Gabriel V. Cornejo, Katherine Marzan, Nancy Liu, Christine Xu, Stephen DiMartino, Angeliki Giannelou, Fei Cao‐Ghoul, Bolanle Akinlade, Lydie Baret‐Cormel   +19 more
wiley   +1 more source

Differential Item Functioning on the Patient Health Questionnaire‐8 by Disease Subtype, Language, Sex, and Age among People with Systemic Sclerosis: A Scleroderma Patient‐centered Intervention Network Cohort Study

Arthritis Care &Research, Accepted Article.
Objective Somatic items used in depression assessments can potentially overlap with symptoms related to physical illness, including systemic sclerosis (SSc). No studies have looked at whether somatic depression items may be influenced by diffuse versus limited SSc disease subtypes, which are associated with varying degrees of symptom presentation.
Sophie Hu, Marie‐Eve Carrier, Marie‐Claude Geoffroy, Meira Golberg, Linda Kwakkenbos, Susan J. Bartlett, Catherine Fortuné, Amy Gietzen, Karen Gottesman, Geneviève Guillot, Laura K. Hummers, Amanda Lawrie‐Jones, Vanessa L. Malcarne, Michelle Richard, Maureen Sauvé, Luc Mouthon, Andrea Benedetti, Brett D. Thombs, The SPIN Investigators, Claire E. Adams, Marie Hudson, Maureen D. Mayes, James Stempel, Robyn K. Wojeck, Christian Agard, Laurent Alric, Marc André, Floryan Beaslay, Elana J. Bernstein, Sabine Berthier, Lyne Bissonnette, Sophie Blaise, Eva Bories, Alessandra Bruns, Carlotta Cacciatore, Patricia Carreira, Marion Casadevall, Benjamin Chaigne, Lorinda Chung, Benjamin Crichi, Thylbert Deltombe, Christopher P. Denton, Tannvir Desroche, Robyn Domsic, James V. Dunne, Bertrand Dunogue, Regina Fare, Dominique Farge‐Bancel, Paul R. Fortin, Loraine Gauzère, Anne Gerber, Jessica K. Gordon, Brigitte Granel‐Rey, Aurélien Guffroy, Geneviève Gyger, Eric Hachulla, Daphna Harel, Monique Hinchcliff, Sabrina Hoa, Michael Hugues, Alena Ikic, Sindhu R. Johnson, Nader Khalidi, Kimberly S. Lakin, Marc Lambert, Maggie Larche, David Launay, Yvonne C. Lee, Paul Legendre, Catarina Leite, Hélène Maillard, Nancy Maltez, Joanne Manning, Isabelle Marie, Maria Martin Lopez, Thierry Martin, Ariel Masetto, Arsène Mekinian, Sheila Melchor Díaz, Morgane Mourguet, Christelle Nguyen, Karen Nielsen, Mandana Nikpour, Louis Olagne, Vincent Poindron, Janet Pope, Susanna Proudman, Grégory Pugnet, Loïc Raffray, François Rannou, Alexis Régent, Frederic Renou, Sébastien Rivière, David Robinson, Esther Rodríguez Almazar, Tatiana Sofia Rodríguez‐Reyna, Sophie Roux, Perrine Smets, Vincent Sobanski, Robert F. Spiera, Virginia Steen, Evelyn Sutton, Carter Thorne, Damien Vagner, John Varga, Pearce Wilcox, Vanessa Cook, Cassidy Dal Santo, Monica D'Onofrio, Elsa‐Lynn Nassar   +109 more
wiley   +1 more source

Transport and profile broadening in the private flux region of ASDEX upgrade and role for power exhaust

Nuclear Fusion
Understanding the transport processes that determine the plasma profile widths in the scrape-off layer (SOL) and divertor region of tokamaks is crucial for successful power and particle exhaust management in future devices.
D. Brida, G. Grenfell, O. Grover, D. Silvagni, M. Faitsch, U. Stroth, the ASDEX Upgrade Team, the EUROfusion Tokamak Exploitation Team   +7 more
doaj   +1 more source

Characterization of the high temperature oxidation behavior of iron based alloys used as exhaust manifolds

MATEC Web of Conferences, 2018
Nowadays engine capacities of vehicles spread in a wide range due to different vehicle power demands. Power density of engines affects exhaust gas and therefore exhaust gas temperature varies from 650 °C to 1000 °C in exhaust manifolds.
Çelik G. Aktaş, Kahrıman Fulya, Atapek Ş. Hakan, Polat Şeyda   +3 more
doaj   +1 more source

Enhancing Corrosion Resistance and Mechanical Strength of 3D‐Printed Iron Polylactic Acid for Marine Applications via Laser Surface Texturing

Advanced Engineering Materials, EarlyView.
Laser surface texturing significantly improves the corrosion resistance and mechanical strength of 3D‐printed iron polylactic acid (Ir‐PLA) for marine applications. Optimal laser parameters reduce corrosion by 80% and enhance tensile strength by 25% and ductility by 15%.
Mohammad Rezayat, Mojtaba Karamimoghadam, Mohammadreza Lalegani Dezaki, Ali Zolfagharian, Giuseppe Casalino, Antonio Mateo, Mahdi Bodaghi   +6 more
wiley   +1 more source

Integrating HVAC condenser airflow and exhaust gas heat for enhanced thermoelectric power generation

Results in Engineering
Interest in capturing waste heat, especially from exhaust gasses, has increased due to the growing need for energy efficiency. By immediately transforming temperature differentials into electrical power, thermoelectric generators (TEGs) provide a ...
Rassol Hamed Rasheed, Ahmed Mohsin Alsayah, Mohammed J. Alshukri, Chadi Nohra, Jalal Faraj, Samer Ali, Mahmoud Khaled   +6 more
doaj   +1 more source

Unlocking the Power of Quercetin‐Encapsulated Mesoporous Bioactive Glass Nanoparticles: A Multifunctional Approach to Bone Regeneration

Advanced Engineering Materials, EarlyView.
Mesoporous bioactive glass nanoparticles (MBGNs) are investigated for bone regeneration given their remarkable structural and functional properties. MBGNs are functionalized with Mn and Cu and incorporated with quercetin, a natural flavonoid exhibiting antioxidant, anti‐inflammatory, and antimicrobial properties.
Giovanni Lo Bello, Qaisar Nawaz, Pier Francesco Ferrari, Laura Pastorino, Roberto Raiteri, Aldo R. Boccaccini   +5 more
wiley   +1 more source

Exploring Microstructure–Physical Property–Corrosion Response Relationship in Intermetallic Compounds of Al‐Cu Bimetallic Interfaces

Advanced Engineering Materials, EarlyView.
Al‐Cu intermetallic compounds (IMCs) have a significant influence on the properties of Al‐Cu bimetallic interfaces formed in compound casting. This article provides a deeper understanding of microstructure, crystallography, thermal properties, hardness, and corrosion response of Al‐Cu IMCs with the goal of facilitating the optimization of the ...
Alireza Nazarahari, Tatiana Blank, Christian Hinte, Huseyin Can Ozdemir, Khemais Barienti, Christian Klose, Dermican Canadinc, Hans Jürgen Maier   +7 more
wiley   +1 more source