Results 81 to 90 of about 1,392,065 (265)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

On the prime power factorization of n!

Journal of Number Theory, 2009
Let \(q_1,~\ldots,~q_k\) be distinct primes. For a prime \(q\) and a positive integer \(n\) let \(e_q(n)\) be the exponent of \(q\) in the factorization of \(n!\). Recently, there has been a lot of interest in studying the distribution of the numbers \(e_{q_1}(n),\ldots,e_{q_k}(n)\) in arithmetic progressions modulo \(m_1,\ldots,m_k\), respectively ...
openaire   +1 more source

Techno-economic evaluation of grid-connected PV generation system based on net metering scheme 3.0 for commercial buildings in Malaysia

EPJ Photovoltaics
The increasing imperative for sustainable energy solutions has significantly amplified the demand for commercial grid-connected photovoltaic (PV) systems, particularly those integrated into rooftop installations within urbanized environments.
Mohamed Hariri Muhammad Hafeez, Joohari Muhammad Imran, Abd Halim Amir Rabani, Mohd Yusoff Nor Azizah Binti, Mohd Jamil Mohamad Kamarol   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Measurement-Based Analysis of Static Var Compensator Effects in Industrial Rolling Mill Grids

Energies
Power quality is a continuous concern in industry, especially in steel mills operating with nonlinear, fluctuating, and unbalanced loads. This paper investigates the influence of a Static Var Compensator (SVC) on power quality parameters in a hot ...
Petru Ivascanu, Manuela Panoiu, Caius Panoiu   +2 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Physical Characteristics of Hydride Perovskites XZrH₃ (X = Mg, Ca, Sr, and Ba) as Materials for Hydrogen Storage: A First-Principles Investigation

Hydrogen
In this study, density functional theory (DFT) within the generalized gradient approximation (GGA) is employed to investigate the structural, electronic, mechanical, and thermoelectric properties of perovskite hydrides XZrH3 (X = Mg, Ca, Sr, Ba ...
Ayoub Koufi, Younes Ziat, Hamza Belkhanchi, Noureddine Elmeskini   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source