Results 91 to 100 of about 1,392,065 (265)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Analysis of Financial Penalties for Low Power Factor in Distribution Systems With High Penetration of Photovoltaics

IEEE Access
Several countries have encouraged the installation of photovoltaic (PV) systems in urban areas to contribute to the decarbonization goals of the electric power system. At the same time, consumers have adopted PV systems to reduce their electricity bills.
Darlene J. Dullius, Victor Gabriel Borges, Renzo Vargas, Caitlin Gusk, Reinaldo Tonkoski, Joel D. Melo, Mahdi Pourakbari Kasmaei   +6 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Colossal Nernst power factor in topological semimetal NbSb₂. [PDF]

Nat Commun, 2022
Li P, Qiu P, Xu Q, Luo J, Xiong Y, Xiao J, Aryal N, Li Q, Chen L, Shi X.   +9 more
europepmc   +1 more source

Designer Entropy Enables High Thermoelectric Power and Efficiency

Interdisciplinary Materials
Thermoelectric (TE) materials promise sustainable energy conversion from waste heat, but their practical utility is often governed by a fundamental trade‐off between conversion efficiency (η) and output power (P).
Yihua Zhang, Yuxuan Yang, Guyang Peng, Haijun Wu, Zhihao Zhao, Jiandong Wang, Tianle Xie, Yuetao Zhang, Yang Zhang, Wanbo Qu, Tong Song, Minghua Yang, Chuansheng Ma, Shengwu Guo, Jun Sun, Xiangdong Ding   +15 more
doaj   +1 more source

Improving Circuit and Transformer Complexity for 24-Pulse AC-DC Converter Topology

IEEE Access
This paper proposes a novel three-phase 24-pulse diode converter topology derived from cascading two 12-pulse rectifiers. Unlike existing designs that use multi-tap Interphase Reactors (IPR) or transformers, our configuration eliminates the need for ...
Gabriel Perilla Galindo, Manuel Perez, German Yamhure, Arturo Fajardo, Carlos-Ivan Paez-Rueda   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Thermoelectric Power-Factor of Ag-Doped TiO₂ Thin Film. [PDF]

Micromachines (Basel), 2022
Usop R, Hasnan MMIM, Mohamad M, Ahmad MK, Said SM, Salleh F.   +5 more
europepmc   +1 more source