Results 111 to 120 of about 4,597,299 (248)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Does Lost Time Cost You Money and Create High Risk? [PDF]

open access: yes, 2012
The aim of the case study is to express the delayed repair time impact on the revenues and profit in numbers with the example of the outage of power plant units.
Fekete, István
core  

COST ALLOCATION OF TRANSMISSION SYSTEMS FOR REACTIVE POWER [PDF]

open access: yesAnnals: Series on engineering sciences (Academy of Romanian Scientists), 2012
In this paper, the authors propose the compute of reactive power allocation considering their losses and their cost using the distribution factors method.
Petru ANDEA   +3 more
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Factors that affect the fatigue strength of power transmission shafting [PDF]

open access: yes
A long standing objective in the design of power transmission shafting is to eliminate excess shaft material without compromising operational reliability.
Loewenthal, S. H.
core   +1 more source

Inflammatory cytokine regulation and behavioral improvement in depressed mice: The role of photobiomodulation

open access: yesJournal of Innovative Optical Health Sciences
In recent years, depression has emerged as a significant global health concern, prompting many individuals to seek pharmacological interventions. The identification of inflammatory changes in the hippocampus of depressed patients has highlighted a ...
Ye Zhang   +5 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Electric Power Generation from Solar Photovoltaic Technology: Is It Marketable in Pakistan? [PDF]

open access: yes
Solar photovoltaic systems are prohibitively expensive in terms of installation costs. Power from them is also available intermittently—only when energy from the sun is available.
A. H. Nayyar   +2 more
core  

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