Results 61 to 70 of about 830,343 (311)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Physics-Guided Residual Learning for Probabilistic Power Flow Analysis

IEEE Access, 2023
Probabilistic power flow (PPF) analysis is critical to power system operation and planning. PPF aims at obtaining probabilistic descriptions of the state of the system with stochastic power injections (e.g., renewable power generation and load demands ...
Kejun Chen, Yu Zhang
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Newton Power Flow Methods for Unbalanced Three-Phase Distribution Networks

Energies, 2017
Two mismatch functions (power or current) and three coordinates (polar, Cartesian and complex form) result in six versions of the Newton–Raphson method for the solution of power flow problems.
Baljinnyam Sereeter, Kees Vuik, Cees Witteveen   +2 more
doaj   +1 more source

Power Flow Analysis on the Dual Input Transmission Mechanism of Small Wind Turbine Systems

Applied Sciences, 2020
A parallel planetary gear train design is proposed to construct the wind turbine system that has double inputs and one output. The proposed system is flexible for the application, which may use a combination of two rotors, as used for horizontal axis or ...
Ah-Der Lin, Tsung-Pin Hung, Jao-Hwa Kuang, Hsiu-An Tsai   +3 more
doaj   +1 more source

A Three-Phase Power Flow Algorithm for Transmission Networks: A Hybrid Phase/Sequence Approach

IEEE Access, 2021
In this paper, the three-phase generalization of a single-phase power flow (named PFPD) developed by the first author is presented. This three-phase formulation is chiefly conceived for HV/EHV transmission network applications, but it preserves a general
Roberto Benato, Giovanni Gardan, Luca Rusalen   +2 more
doaj   +1 more source

An Affine Arithmetic-Based Methodology for Reliable Power Flow Analysis in the Presence of Data Uncertainty [PDF]

, 2009
(© 2010 IEEE) Vaccaro, A., Canizares, C. A., & Villacci, D. (2010). An affine arithmetic-based methodology for reliable power flow analysis in the presence of data uncertainty. IEEE Transactions on Power Systems, 25(2), 624–632.
Canizares, Claudio A., Villacci, Domenico, Vaccaro, Alfredo   +2 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

The Use of a Complex Network with NetworkX and Neplan Software for the Analysis of a Power Transmission System

Technologies
The evolution of electrical energy in all its aspects is one of the biggest challenges facing the operation of modern power systems. With the addition of numerous new, networked components to these systems, such as intelligent devices, electric vehicles,
Arbër Perçuku, Daniela Minkovska, Nikolay Hinov   +2 more
doaj   +1 more source