Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The power flow coloring: Giving a unique ID to a power flow from a specific power source to a specific power load [PDF]
, 2015 The increasing number of renewable energy sources requires new approaches for the management of the electricity grid in order to sustain or even to improve the power supply quality.
Kato, Takekazu +3 more
core
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
MiR‐513a promotes human erythroid differentiation by modulating c‐Jun
FEBS Open Bio, EarlyView.During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim +11 more
wiley +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Three-Port Multifunctional Railway Power Conditioner Integrated with Energy Storage Systems for Regenerative Braking Energy and Power Quality Control [PDF]
International Journal of Railway Research, 2020 Electrical railway systems (ERSs) are one of the largest end-users in the utility grid. Providing optimal energy management and improving efficiency in such a high-power network is a vital approach to conserve energy and decrease economic costs ...
Hamed Jafari Kaleybar, Seyed Saeed Fazel
doaj
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Impact of wind power on the unit commitment, operating reserves and market design
, 2011 Paper presented at the 2011 IEEE Power and Energy Society General Meeting, San Diego, CA, 24-29 July 2011This article highlights and demonstrates the new requirements variable and partly unpredictable wind power will bring to unit commitment and power ...
Milligan, M. +25 more
core +1 more source
Modeling and Control of a Marine Current Turbine Driven Doubly-Fed Induction Generator [PDF]
, 2010 This paper deals with the modeling and the control of a variable speed DFIG-based marine current turbine with and without tidal current speed sensor.
BENELGHALI, Seifeddine +3 more
core +1 more source