Results 61 to 70 of about 254,638 (264)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Simplicial complexes defined on groups

Open Mathematics
This study makes some preliminary observations towards an extension of current work on graphs defined on groups to simplicial complexes. I define a variety of simplicial complexes on a group, which are preserved by automorphisms of the group, and in many
Cameron Peter J.
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Some Characterizations and NP-Complete Problems for Power Cordial Graphs

Journal of Mathematics, 2023
A power cordial labeling of a graph G=VG,EG is a bijection f:VG⟶1,2,…,VG such that an edge e=uv is assigned the label 1 if fu=fvn or fv=fun, for some n∈N∪0 and the label 0 otherwise, and satisfy the number of edges labeled with 0 and the number of edges ...
C. M. Barasara, Y. B. Thakkar
doaj   +1 more source

SOME GRAPH PARAMETERS OF POWER SET GRAPHS

Advances and Applications in Discrete Mathematics, 2021
In this study, we examine some graph parameters such as the edge number, chromatic number, girth, domination number and clique number of power set graphs.
Cangül, İsmail Naci, Pak, Sedat, Akgüneş, Nihat, Nacaroğlu, Yaşar   +3 more
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Power domination in maximal planar graphs [PDF]

Discrete Mathematics & Theoretical Computer Science, 2019
Power domination in graphs emerged from the problem of monitoring an electrical system by placing as few measurement devices in the system as possible. It corresponds to a variant of domination that includes the possibility of propagation.
Paul Dorbec, Antonio González, Claire Pennarun   +2 more
doaj   +1 more source

Between the enhanced power graph and the commuting graph

Journal of Graph Theory, 2022
AbstractThe purpose of this note is to define a graph whose vertex set is a finite group , whose edge set is contained in that of the commuting graph of and contains the enhanced power graph of . We call this graph the deep commuting graph of . Two elements of are joined in the deep commuting graph if and only if their inverse images in every central ...
Peter J. Cameron, Bojan Kuzma
openaire   +4 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

What can graphs and algebraic structures say to each other?

AKCE International Journal of Graphs and Combinatorics
In the last couple of decades, there has been a big upsurge of research on graphs defined on algebraic structures (groups, rings, vector spaces, semigroups, and others).
Peter J. Cameron
doaj   +1 more source