Results 101 to 110 of about 272,972 (308)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Distribution-graph based approach and extended tree growing technique in power-constrained block-test scheduling [PDF]

, 2000
A distribution-graph based scheduling algorithm is proposed together with an extended tree growing technique to deal with the problem of unequal-length block-test scheduling under power dissipation constraints. The extended tree growing technique is used
Wang, Xiaojun, V. Murescan, Muresan, Valentina, Xiaojun Wang, Muresan, Valentin, M. Vladutiu, Vladutiu, M.   +6 more
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Review of the Application of Graph Database and Graph Computing in Power System Dispatch and Operation

Zhongguo dianli
As the widespread integration of new energy and interconnection of large power grids, the operation modes of power systems are undergoing transformations, which leads to a fast surge in data volumes and higher demands for real-time information processing,
Pei ZHANG, Majing YANG, Fang ZHANG, Hua XIE, Guangyi LIU, Wenyun LI, Xuegang LU, Zhenyi WANG, Suwei ZHAI   +8 more
doaj   +1 more source

Distinguishing Cartesian Powers of Graphs [PDF]

The Electronic Journal of Combinatorics, 2005
Given a graph $G$, a labeling $c:V(G) \rightarrow \{1, 2, \ldots, d\}$ is said to be $d$-distinguishing if the only element in ${\rm Aut}(G)$ that preserves the labels is the identity. The distinguishing number of $G$, denoted by $D(G)$, is the minimum $d$ such that $G$ has a $d$-distinguishing labeling.
openaire   +2 more sources

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Brooks’ theorem on powers of graphs

Discrete Mathematics, 2014
We prove that for $k\geq 3$, the bound given by Brooks' theorem on the chromatic number of $k$-th powers of graphs of maximum degree $Δ\geq 3$ can be lowered by 1, even in the case of online list coloring.
Bonamy, Marthe, Bousquet, Nicolas
openaire   +3 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The nonsolvability by radicals of generic 3-connected planar Laman graphs. [PDF]

, 2007
We show that planar embeddable -connected Laman graphs are generically non-soluble. A Laman graph represents a configuration of points on the Euclidean plane with just enough distance specifications between them to ensure rigidity.
Power, Stephen C., Owen, J. C.
core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source