Results 101 to 110 of about 4,604,675 (299)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Comparative Analysis of Power Losses in the Single-Flow LS-Systems with Pump and Valve Configuration

Механика машин, механизмов и материалов, 2018
The power losses in the single-flow hydraulic LS-systems with a pump configuration (using the variable displacement LS-pump) and with a valve configuration (using the fixed displacement pump) are investigated.
Aleksander A. Hinzburh, Dmitriy L. Stasenko   +1 more
doaj  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Minimizing Power Loss Using Modified Artificial Bee Colony Algorithm

Journal of Computing Research and Innovation, 2021
Electrical energy losses are found in any part of the power system. In the power system, it is essential to minimize the real power loss in transmission lines.
Nur Azlin Ashiqin Mohd Amin, Siti Hafawati Jamaluddin, Nur Syuhada Muhammat Pazil, Norwaziah Mahmud, Norhanisa Kimpol   +4 more
doaj  

Optimal Number, Location, and Size of Distributed Generators in Distribution Systems by Symbiotic Organism Search Based Method

Advances in Electrical and Electronic Engineering, 2017
This paper proposes an approach based on the Symbiotic Organism Search (SOS) for optimal determining sizing, siting, and number of Distributed Generations (DG) in distribution systems.
Tri Phuoc Nguyen, Dieu Ngoc Vo, Tung The Tran   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Comprehensive Power Losses Model for Electronic Power Transformer

IEEE Access, 2018
The electronic power transformer (EPT) has higher power losses than the conventional transformer. However, the EPT can correct the power factor, compensate the unbalanced current, and reduce the line power losses in the distribution network. Therefore, the higher power losses of the EPT and the consequent reduced power losses in the distribution ...
Quanyou Yue, Canbing Li, Yijia Cao, Yuqing He, Binglin Cai, Qiuwei Wu, Bin Zhou   +6 more
openaire   +3 more sources

Performance analysis of radiation cooled dc transmission lines for high power space systems [PDF]

As space power levels increase to meet mission objectives and also as the transmission distance between power source and load increases, the mass, volume, power loss, and operating voltage and temperature become important system design considerations ...
Schwarze, G. E.
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source