Results 41 to 50 of about 447,314 (268)
The Power of Boolean Implication Networks [PDF]
Frontiers in Physiology, 2012 Human diseases have been investigated in the context of single genes as well as complex networks of genes. Though single gene approaches have been extremely successful in the past, most human diseases are complex and better characterized by multiple interacting genes commonly known as networks or pathways.
openaire +3 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Space Weather, 2022 Space Weather phenomena pose a major socio‐economic threat due, in part, to the vulnerability of power network transformers to geomagnetically induced currents (GIC).
S. Marsal +3 more
doaj +1 more source
Power Network Optimization: A Quantum Approach
IEEE Access, 2023 Optimization of electricity surplus is a crucial element for transmission power networks since it leads to reducing costs as well as increasing efficiency across the network as a whole.
Giuseppe Colucci +2 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Известия высших учебных заведений: Проблемы энергетики, 2019 : The article presents an algorithm for estimating reliability parameters - probability of failure-free operation time and failure rate of low-voltage switching devices based on statistical data on failures of circuit breakers installed in control and ...
E. I. Gracheva +3 more
doaj +1 more source
Proof-of-PUF Enabled Blockchain: Concurrent Data and Device Security for Internet-of-Energy
Sensors, 2020 A detailed review on the technological aspects of Blockchain and Physical Unclonable Functions (PUFs) is presented in this article. It stipulates an emerging concept of Blockchain that integrates hardware security primitives via PUFs to solve bandwidth ...
Rameez Asif, Kinan Ghanem, James Irvine
doaj +1 more source