Results 61 to 70 of about 447,314 (268)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

PowerX: A Probabilistic Graph Model for Complex Smart Grid Networks

IEEE Access
Smart grid power networks are essential for addressing the global energy crisis and combating climate change. In the past few decades, information and communication infrastructure have greatly improved.
Muhammad Irfan, Abdelrahman B. M. Eldaly, Rizwan Qureshi, Muhammad Bilal, Muhammad Shehzad Hanif   +4 more
doaj   +1 more source

Computing power network: A survey

China Communications
With the rapid development of cloud computing, edge computing, and smart devices, computing power resources indicate a trend of ubiquitous deployment. The traditional network architecture cannot efficiently leverage these distributed computing power resources due to computing power island effect.
Yukun Sun, Junlin Liu, Haonan Huang, Xing Zhang 0001, Bo Lei 0002, Jing Peng, Wenbo Wang 0007   +6 more
openaire   +2 more sources

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

A Robust Distributed Algorithm for Solving the Economic Dispatch Problem with the Penetration of Renewables and Battery Systems

Applied Sciences
In the field of energy networks, for their effective functioning, it is necessary to distribute the required load between all online generating units in a proper way to cover the demand.
Karel Kubicek, Martin Cech, Martin Strelec   +2 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

De Ginásio à Escola Superior

Terra Brasilis
The general objective of this study is to analyze the power networks responsible for the implementation of the “Ginásio” (1913), the “Escola Normal Nossa Senhora do Carmo” (1914) and the “Escola Superior de Agricultura e Veterinária” (1922), in Viçosa-MG,
Dayana Debossan, Maria Isabel de Jesus Chrysostomo   +1 more
doaj   +1 more source

Multivariable Control of Solar Battery Power by Extremum Seeking: Starting from Linear Analysis

Machines, 2019
In this study, we tried to combine maximum power point trackers (MPPT) and «Extremum Seeking» in a single multi-parameter extremum seekeng system for orienting solar panels and draw attention to the problem of a deeper study of nonlinear ...
I. M. Kirpichnikova, A. Yu. Sologubov
doaj   +1 more source