Results 71 to 80 of about 447,314 (268)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

COMPARATIVE ANALYSIS OF METHODS OF CALCULATION AND ERRORS OF ACTIVE POWER LOSSES IN LOW VOLTAGE COMMERCIAL NETWORKS

open access: yesИзвестия высших учебных заведений: Проблемы энергетики, 2019
The article analyzes some methods for calculating the loss of active power in lowvoltage industrial networks, taking into account the main influencing parameters.
E. I. Gracheva   +2 more
doaj   +1 more source

Crime, Networks and Power

open access: yes, 2016
Un'analisi delle trasformazioni strutturali di Cosa Nostra siciliana sotto il paradigma postfordista.
openaire   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Partidos políticos, redes corporativas y formación de gabinetes en Costa Rica: 1986-2010

open access: yesRevista de Ciencias Sociales, 2011
El artículo discute aspectos centrales del debate sobre partidos políticos y redes de poder, se concentra en analizar empíricamente la presencia de tales actores dentro de los partidos políticos y su presencia determinante en la formación de los ...
Randall Blanco Lizano
doaj   +1 more source

Visual power networking

open access: yes, 2007
Visual Power Networking is a facilitation technique best suited for the early phases of a conference, when delegates should get to know each other and initial contacts should be made amongst delegates.
Wolf, P., Troxler, P., Kazi, Abdul Samad
openaire   +1 more source

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