Results 61 to 70 of about 189,528,022 (311)

Selecting Operating Conditions of Power MOSFETs in a Power Cycling Test Based on Thermal Time Constants

open access: yesEnergies
This paper presents the results of research on the effect of temperature on damage processes occurring in power MOSFETs. The impact of changes in the activation energy of selected mechanisms initiating the damage process in power MOSFETs during ...
Krzysztof Górecki, Paweł Górecki
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

A powerful and versatile colocalization test

open access: yesPLOS Computational Biology, 2020
Transcriptome-wide association studies (TWAS and PrediXcan) have been increasingly applied to detect associations between genetically predicted gene expressions and GWAS traits, which may suggest, however do not completely determine, causal genes for GWAS traits, due to the likely violation of their imposed strong assumptions for causal inference ...
Yangqing Deng, Wei Pan 0011
openaire   +4 more sources

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

New statistical high power test, obtained by differentiating random data of a small sample

open access: yesИзвестия высших учебных заведений. Поволжский регион:Технические науки, 2021
Background. The research considers the problem of statistical analysis of small samples by synthesizing new statistical criteria. Materials and methods.
A.I. Ivanov   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

The Design and Life Test of a Multifunction Power Amplifier for Space Application

open access: yesActive and Passive Electronic Components, 2016
A new multifunction power amplifier (MFPA) is designed and fabricated for the application of point-to-point K-Band backhaul TR module. A DC temperature life test was performed to model the up-limit temperature effect of the designed MFPA under space ...
Xiuqin Xu   +8 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Tractor Testing; Belt Power Test; Caterpillar

open access: yes, 1949
Caterpillar D4 diesel during belt test. Caterpillar D4 diesel crawler inside the old tractor test lab with a belt running from the rear of the tractor to the dynamometer inside the control ...
Nebraska Tractor Test Laboratory
core  

Non-central t distribution and the power of the t test: A rejoinder [PDF]

open access: yesTutorials in Quantitative Methods for Psychology, 2011
Non-central t distribution needed for assessing the power of the t test is described. Three approximations are compared and their merits discussed in regard to simplicity and accuracy.
Denis Cousineau, Louis Laurencelle
doaj  

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