Results 61 to 70 of about 6,587,859 (292)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Diverging nonlocal fields: Operationalizing critical disability physics identity with neurodivergent physicists outside academia

Physical Review Physics Education Research
Science, technology, engineering, and mathematics (STEM) education research and physics education research, in particular, are currently struggling with a dearth of research into understanding the experiences and identity development of neurodivergent ...
Liam G. McDermott, Nazeer A. Mosley, Geraldine L. Cochran   +2 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Analytical solution of driven time-dependent mesoscopic circuits

Scientific Reports
When a time-dependent harmonic system is further driven by an external source, it presents significant challenges to obtaining analytical solutions for the system.
Jinying Ma, Yazhuo Yao, Ronghai Liu, Fangcheng Qiu, Xiyuan Zhang, Zhanyuan Yan   +5 more
doaj   +1 more source

Physics and nuclear power

Journal of Physics: Conference Series, 2008
Nuclear power owes its origin to physicists. Fission was demonstrated by physicists and chemists and the first nuclear reactor project was led by physicists. However as nuclear power was harnessed to produce electricity the role of the engineer became stronger.
openaire   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The ground states of hidden-charm tetraquarks and their radial excitations

European Physical Journal C: Particles and Fields
Inspired by the great progress in the observations of charmonium-like states in recent years, we perform a systematic analysis about the ground states and the first radially excited states of $$qc\bar{q}\bar{c}$$ q c q ¯ c ¯ (q = u/d and s) tetraquark ...
Guo-Liang Yu, Zhen-Yu Li, Zhi-Gang Wang, Bin Wu, Ze Zhou, Jie Lu   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Microscopic nature of the photon strength function: stable and unstable Ni and Sn isotopes

EPJ Web of Conferences, 2015
The pygmy-dipole resonances and photon strength functions in stable and unstable Ni and Sn isotopes are calculated within the microscopic self-consistent version of the Extended Theory of Finite Fermi Systems that includes the QRPA and phonon coupling ...
Achakovskiy Oleg, Avdeenkov Alexander, Goriely Stephane, Kamerdzhiev Sergei, Krewald Siegfried, Voitenkov Dmitriy   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source