Results 61 to 70 of about 262,017 (315)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Physical Review Physics Education ResearchScience, technology, engineering, and mathematics (STEM) education research and physics education research, in particular, are currently struggling with a dearth of research into understanding the experiences and identity development of neurodivergent ...
Liam G. McDermott +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Physics-Based Power Device Models in SABER - Implementation Issues
, 2000 In this paper, the implementation issues of physics-based power device models in the SABER circuit simulator through the MAST High Description Language (HDL) are discussed.
Kolessar, Remy,, Nee, Hans-Peter,
core +1 more source
New physics contributions to moments of inclusive b → c semileptonic decays
, 2022 Inclusive semileptonic B →$ {X}_c\ell {\overline{\nu}}_{\ell } $ decays, where ℓ = μ, e, are by now standard candles in the determination of the CKM element |V$_{cb}$|.
Vos, K.K. +9 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The ground states of hidden-charm tetraquarks and their radial excitations
European Physical Journal C: Particles and FieldsInspired by the great progress in the observations of charmonium-like states in recent years, we perform a systematic analysis about the ground states and the first radially excited states of $$qc\bar{q}\bar{c}$$ q c q ¯ c ¯ (q = u/d and s) tetraquark ...
Guo-Liang Yu +5 more
doaj +1 more source
Publisher Copyright: © 2025 Elsevier Ltd.The ever-growing use of wind energy requires the optimization of turbine operations through pitch angle controllers and early fault detection.
Gómez-Romero, Juan +4 more
core +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source