Results 81 to 90 of about 203,307 (268)

An alternating segment Crank–Nicolson parallel difference scheme for the time fractional sub-diffusion equation

Advances in Difference Equations, 2018
In this paper, an alternating segment Crank–Nicolson (ASC-N) parallel difference scheme is proposed for the time fractional sub-diffusion equation, which consists of the classical Crank–Nicolson scheme, four kinds of Saul’yev asymmetric schemes, and ...
Lifei Wu, Xiaozhong Yang, Yanhua Cao
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Development and operation of a 100 W wave energy converter for persistent ocean observation

Scientific Reports
Much of the existing literature for wave energy converters focuses on devices tailored to grid-scale performance. In this paper, we present the development of TigerRAY, a small, blue-economy scale wave energy converter, designed to generate 100 W in ...
Curtis J. Rusch, Erik Hammagren, Joe Prudell, Zhe Zhang, Jim Thomson   +4 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Suppression of pathological beta oscillations in Parkinson’s disease by delayed feedback control targeting the thalamic nucleus-cortex direct pathway [PDF]

AIP Advances
The motor symptoms of Parkinson’s disease are closely associated with pathological neural oscillations within the cortico-basal ganglia circuit. Although deep brain stimulation (DBS) can alleviate symptoms by suppressing abnormal oscillatory activity ...
Ziyang Wang, Suyuan Huang, Yuan Chai, Jingjing Yang, Rui Zhu   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Graph Distance and Adaptive K-Nearest Neighbors Selection-Based Density Peak Clustering

IEEE Access
Density Peak Clustering (DPC) is known for its rapid identification of cluster centers and successful clustering tasks. However, traditional DPC encounters several issues, which include simplifications in local density and distance metrics, a non-robust ...
Yuqin Sun, Jingcong Wang, Yuan Sun, Pengcheng Zhang, Tianyi Wang   +4 more
doaj   +1 more source