Results 101 to 110 of about 191,581 (267)
White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian +8 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers +19 more
wiley +1 more source
Upper Cervical Cord Area as a Biomarker of Conversion to Secondary Progressive Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study assessed whether upper cervical cord area (UCCA) measured on routine brain MRI can serve as a biomarker of conversion to SPMS. Methods This is a single‐center retrospective cohort study of RRMS patients with cross‐sectional and longitudinal analyses of clinical and MRI data. Future SPMS converters were matched by age, sex,
Nabil K. El Ayoubi +8 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand +5 more
wiley +1 more source
Photovoltaic Scenario Generation via Multimodal Fusion and Local Window Attention
IEEE AccessThe large-scale integration of photovoltaic (PV) power intensifies the uncertainty of electrical grids. Abrupt changes in PV output during diurnal transitions present challenges for high-resolution scenario generation due to deficiencies in multimodal ...
Zhipeng Kang +3 more
doaj +1 more source
The Multiple Sclerosis Severity Allele rs10191329A and Cognitive Function: A UK Biobank Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT The genome‐wide association study of Multiple Sclerosis severity linked the genetic variant rs10191329A to long‐term disability and implicated brain resilience as a determinant of outcome. We hypothesised that rs10191329A might influence cognition in other neurological diseases and healthy controls.
Ioanna Zimianiti +5 more
wiley +1 more source
本文提出了一个描述社会权力动态的一般数学框架。与基于博弈论的传统模型不同,本研究采用了基于矢量微积分和非平衡热力学的方法。通过定义实体、资源和系统的几何属性,本文建立了五个基本公理,并推导出一组耦合微分方程——称为“三位一体方程”——描述系统的状态、成本和未来。该模型量化了系统几何相干性与资源耗散速率之间的函数关系,并展示了“功率方差”与“技术演变”之间的动态排斥定律。这项工作揭示了权力结构不可避免地趋向自我腐蚀的物理机制,为定量历史分析提供了一种新颖的理论工具。 本文提出了一种描述社会权力动力学的通用数学框架。不同于基于博弈论的传统模型,本研究采用了基于向量微积分和非平衡态热力学的方法。通过定义实体、资源与系统的几何属性,本文建立了五条基础公理,并推导出一组描述系统状态 ...
openaire +2 more sources
Bi‐ and Mono‐Allelic RFC1 Expansion in a North American Cohort With Idiopathic Axonal Neuropathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective RFC1 biallelic repeat expansion is increasingly recognized as a cause of chronic idiopathic axonal polyneuropathy (CIAP), but it remains challenging to know who to test. This study aims to determine the prevalence of biallelic and monoallelic RFC1 expansions and their corresponding neuropathy phenotypes in CIAP patients and identify ...
Amro M. Stino +25 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To determine whether myelin‐sensitive quantitative MRI reveals microstructural abnormalities in normal‐appearing cortex (NACtx) in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), indicating that conventional MRI underestimates remission residual cortical injury.
Valentina Camera +20 more
wiley +1 more source