Results 91 to 100 of about 1,794,390 (295)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Reactor monitoring and safeguards using antineutrino detectors

, 2008
Nuclear reactors have served as the antineutrino source for many fundamental physics experiments. The techniques developed by these experiments make it possible to use these very weakly interacting particles for a practical purpose.
Applied Antineutrino Physics, Applied Antineutrino Physics, Ardellier F, Bowden N S, Collar J, Dazeley S, Fallot M, Guillian E, Mention G, Mikaelian L A, Monteith A, N S Bowden, Neutrino Sciences, Neutrinos, Porta A, Sinev V, Suekane F   +16 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Suppression of pathological beta oscillations in Parkinson’s disease by delayed feedback control targeting the thalamic nucleus-cortex direct pathway [PDF]

AIP Advances
The motor symptoms of Parkinson’s disease are closely associated with pathological neural oscillations within the cortico-basal ganglia circuit. Although deep brain stimulation (DBS) can alleviate symptoms by suppressing abnormal oscillatory activity ...
Ziyang Wang, Suyuan Huang, Yuan Chai, Jingjing Yang, Rui Zhu   +4 more
doaj   +1 more source

Photoemission Spectroscopy and the Unusually Robust One Dimensional Physics of Lithium Purple Bronze

, 2013
Temperature dependent photoemission spectroscopy in Li0.9Mo6O17 contributes to evidence for one dimensional physics that is unusually robust. Three generic characteristics of the Luttinger liquid are observed, power law behavior of the k-integrated ...
A Sekiyama, Chen H, D Hitchcock, F Wang, Giamarchi T, He J, J D Denlinger, J He, J W Allen, L Dudy, Matsuda Y, Mercure J F, Orgad D, Pouget J P, S Suga, Sachdev S, Sato M, Satpathy S   +17 more
core   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Plasma physics and environmental perturbation laboratory. Volume 1: Executive summary [PDF]

Space physics and plasma physics experiments that can be performed from the space shuttle were identified. Potential experiment concepts were analyzed to derive requirements for a spaceborne experiment facility.

core   +1 more source

Statistical physics of power fluctuations in mode locked lasers

, 2008
We present an analysis of the power fluctuations in the statistical steady state of a passively mode locked laser. We use statistical light-mode theory to map this problem to that of fluctuations in a reference equilibrium statistical physics problem ...
C. W. Gardiner, F. W. J. Olver, L. D. Landau, Oded Basis, Omri Gat   +4 more
core   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source