Results 111 to 120 of about 1,973,234 (348)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Energies, 2017 The Organic Rankine Cycle (ORC) is a promising form of technology for recovering low-grade waste heat. In this study, a regenerative ORC system is established to recover the waste flue gas of 160 °C.
Zhonghe Han +4 more
doaj +1 more source
The financial crisis and nuclear power [PDF]
, 2009 An assessment of the impact of the financial crisis on the prospects for new nuclear power plant orders ...
Hall, David, Thomas, Stephen
core
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
The Guy at the Controls: Labor Quality and Power Plant Efficiency [PDF]
This paper examines the impact of individual human operators on the fuel efficiency of power plants. Although electricity generation is a fuel and capital intensive enterprise, anecdotal evidence, interviews, and empirical analysis support the hypothesis
Catherine Wolfram, James B. Bushnell
core
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Visualization of surface discharge area in SF6 based on infrared trap
AIP AdvancesA method for visualization of surface discharge area in SF6 based on infrared trap is proposed in this study. The infrared images of a heated insulator with a surface defect under different applied voltages were studied, and the infrared trap phenomenon ...
Xinzhi Yang +7 more
doaj +1 more source
EnergiesIn response to the limitations of traditional single-signal approaches, which fail to comprehensively reflect fault conditions, and the difficulties of existing feature extraction methods in capturing subtle fault patterns in transformer fault diagnosis,
Mingtao Yu +9 more
doaj +1 more source
Energy Conversion Alternatives Study (ECAS), Westinghouse phase 1. Volume 5: Combined gas-steam turbine cycles [PDF]
The energy conversion efficiency of gas-steam turbine cycles was investigated for selected combined cycle power plants. Results indicate that it is possible for combined cycle gas-steam turbine power plants to have efficiencies several point higher than ...
Amos, D. J. +2 more
core +1 more source